ChemicalBook >> CAS DataBase List >>HOMOGENTISIC ACID
HOMOGENTISIC ACID
- CAS No.
- 451-13-8
- Chemical Name:
- HOMOGENTISIC ACID
- Synonyms
- 2-(2,5-dihydroxyphenyl)acetic acid;alcapton;Melanic acid;homogentisicaci;HOMOGENTISIC ACID;Homogentisinic acid;HOMOGENTISIC ACID(RG);Homogentisic Acid >Homogentisic Acid, ≥ 97.0%;2,5-Dihydroxy-α-toluic acid
- CBNumber:
- CB5207860
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00004324
- MOL File:
- 451-13-8.mol
- MSDS File:
- SDS
Last updated:2024-08-05 12:01:54
| Melting point | 150-152 °C (lit.) |
|---|---|
| Boiling point | 257.07°C (rough estimate) |
| Density | 1.3037 (rough estimate) |
| refractive index | 1.5090 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in methanol. |
| pka | 4.4(at 25℃) |
| form | crystalline |
| color | off-white to tan |
| Water Solubility | very faint turbidity |
| Merck | 14,4737 |
| BRN | 2692860 |
| LogP | 0.860 |
| CAS DataBase Reference | 451-13-8(CAS DataBase Reference) |
| FDA UNII | NP8UE6VF08 |
| EPA Substance Registry System | Benzeneacetic acid, 2,5-dihydroxy- (451-13-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AH0589000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
HOMOGENTISIC ACID price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H0751 | Homogentisic acid crystalline | 451-13-8 | 100mg | $140 | 2024-03-01 | Buy |
| Sigma-Aldrich | H0751 | Homogentisic acid crystalline | 451-13-8 | 500mg | $351 | 2024-03-01 | Buy |
| Sigma-Aldrich | 92168 | Homogentisic acid analytical standard | 451-13-8 | 25MG | $126 | 2022-05-15 | Buy |
| TCI Chemical | D1050 | Homogentisic Acid >97.0%(HPLC)(T) | 451-13-8 | 1g | $287 | 2024-03-01 | Buy |
| TCI Chemical | D1050 | Homogentisic Acid >97.0%(HPLC)(T) | 451-13-8 | 5g | $923 | 2024-03-01 | Buy |
HOMOGENTISIC ACID Chemical Properties,Uses,Production
Chemical Properties
off-white to tan crystals or crystalline powder
Uses
An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.
Uses
Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
- Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
- Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).
It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).
Definition
ChEBI: Homogentisic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions. It has a role as a human metabolite and a plant metabolite. It is a dihydroxyphenylacetic acid and a member of hydroquinones. It is functionally related to a phenylacetic acid. It is a conjugate acid of a homogentisate.
General Description
Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.
Purification Methods
Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]
HOMOGENTISIC ACID Preparation Products And Raw materials
Global( 137)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3002 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13432 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9725 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 |
View Lastest Price from HOMOGENTISIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-05 | HOMOGENTISIC ACID
451-13-8
|
US $25.00-12.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-14 | HOMOGENTISIC ACID
451-13-8
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- HOMOGENTISIC ACID
451-13-8
- US $25.00-12.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- HOMOGENTISIC ACID
451-13-8
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
451-13-8(HOMOGENTISIC ACID)Related Search:
HOMOGENTISIC ACID
2,5-DIHYDROXY-1,4-BENZENEDIACETIC ACID
(2,5-Dimethoxyphenyl)acetic acid
2-(METHOXY)-5-(TRIFLUOROMETHOXY)PHENYLACETIC ACID
HOMOGENTISIC ACID LACTONE,HOMOGENTISIC ACID GAMMA-LACTONE
Phenylacetic acid
2,5-DIBENZYLOXYPHENYLACETIC ACID
HOMOGENTISIC ACID, [RING-3H]
AMINO-(2,4,5-TRIMETHOXY-PHENYL)-ACETIC ACID
HOMOGENTISIC ACID ETHYL ESTER
1of4
(2,5-dihydroxyphenyl)-aceticaci
2,5-dihydroxy-benzeneaceticaci
2,5-dihydroxybenzeneaceticacid
alcapton
Homogentisic acid 2,5-Dihydroxyphenylacetic acid
homogentisic acid free acid
Benzeneacetic acid,2,5-dihydroxy-
HoMogentisic acid crystalline
HOMOGENTISIC ACID(RG)
2,5-Dihydroxy-α-toluic acid
Homogentisinic acid
2,5-Dihydroxyphenylacetic acid,95%
2,5-Dihydroxyphenylacetic acid,99%
1,4-HYDROQUINONEACETIC ACID
HOMOGENTISIC ACID
2,5-DIHYDROXYPHENYLACETIC ACID
2-(2,5-dihydroxyphenyl)acetate
Homogentisic Acid >
Melanic acid
homogentisicaci
5-dihydroxy-benzeneaceticaci
2,5-Dihydroxyphenylacetic acid, 97%,
2-(2,5-dihydroxyphenyl)acetic acid
Homogentisic Acid, ≥ 97.0%
451-13-8
HO2C6H3CH2COOH
Metabolomics
Metabolic Libraries
Organic Building Blocks
Building Blocks
BioChemical
Amino Acid Library
C8
Carbonyl Compounds
Carboxylic Acids
Aromatic Phenylacetic Acids and Derivatives
Aromatics
Intermediates