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Halofuginone Lactate

CAS No.
82186-71-8
Chemical Name:
Halofuginone Lactate
Synonyms
halofuginonlactat;Athoxanone lactone;HALOFUGINONE LACTATE;GATQERNJKZPJNX-LDXVYITESA-N;7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-quinazolinone;2-hydroxypropanoic acid - 7-bromo-6-chloro-3-{3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one (1:1)
CBNumber:
CB5210970
Molecular Formula:
C19H23BrClN3O6
Molecular Weight:
504.76
MDL Number:
MFCD00144429
MOL File:
82186-71-8.mol
MSDS File:
SDS
Last updated:2024-11-18 17:01:59

Halofuginone Lactate Properties

storage temp. 0-6°C
FDA UNII 6ZO4HT041C

Halofuginone Lactate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC H102480 HalofuginoneLactate 82186-71-8 1mg $185 2021-12-16 Buy
Biosynth Carbosynth FH31606 Halofuginone lactate 82186-71-8 100mg $240 2021-12-16 Buy
Biosynth Carbosynth FH31606 Halofuginone lactate 82186-71-8 25mg $100 2021-12-16 Buy
Biosynth Carbosynth FH31606 Halofuginone lactate 82186-71-8 50mg $150 2021-12-16 Buy
Biosynth Carbosynth FH31606 Halofuginone lactate 82186-71-8 250mg $450 2021-12-16 Buy
Product number Packaging Price Buy
H102480 1mg $185 Buy
FH31606 100mg $240 Buy
FH31606 25mg $100 Buy
FH31606 50mg $150 Buy
FH31606 250mg $450 Buy

Halofuginone Lactate Chemical Properties,Uses,Production

Description

Halofuginone Lactate is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.

Uses

Halofuginone is a halogenated derivative of Febrifugine (F228500). Halofuginone is used as an antiprotozoal. It is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.
Integration of halofuginone lactate treatment and disinfection with p-chloro-m-cresol to control natural cryptosporidiosis in calves

Application

Halofuginone lactate is a synthetic product of the quinazolinone group with antiprotozoal activity, especially against Coccidia and Theileria species. It is effective in many cases of calf cryptosporidiosis, as has been shown in studies in Europe and Canada. Also, halofuginone is effective in lamb cryptosporidiosis. Halofuginone prevented natural infections in kids in France and in Greece[1].

Pharmacokinetics

Halofuginone lactate is a salt whose antiprotozoal properties and efficacy against Cryptosporidium parvum have been demonstrated both in in vitro conditions and artificial and natural infections. The compound has a cryptosporidiostatic effect on Cryptosporidium parvum. It is mainly active in the free stages of the parasite (sporozo?te, merozo?te). The concentrations to inhibit 50% and 90% of the parasites in an in vitro test system are IC50 < 0.1 μg/ml and IC90 of 4.5 μg/ml, respectively. The bioavailability of the drug in the calf following a single oral administration is about 80%. The time necessary to obtain the maximum concentration Tmax is 11 hours. The maximum concentration in plasma Cmax is 4 ng/ml. The apparent volume of distribution is 10 l/kg. The plasmatic concentrations of halofuginone after repeated oral administrations are comparable to the pharmacokinetic pattern after a single oral treatment. Unchanged halofuginone is the major component in the tissues. The highest values have been found in the liver and the kidney. The product is mainly excreted in the urine. The terminal elimination half-life is 11.7 hours after IV administration and 30.84 hours after single oral administration.

References

[1] N.D. Giadinis . “Efficacy of halofuginone lactate for the treatment and prevention of cryptosporidiosis in goat kids: An extensive field trial.” Small Ruminant Research 76 3 (2008): Pages 195-200.

Halofuginone Lactate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 48 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20284 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10319 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Hainan Mike Biomedical Technology Co., Ltd
+86-15120707353 +86-18876637353 tunanmedicine@hotemail.com China 43 58

View Lastest Price from Halofuginone Lactate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Halofuginone  lactate pictures 2024-12-23 Halofuginone lactate
82186-71-8
US $10.00 / kg 25kg 99% 10000kg /year Enki Biopharmaceuticals (Shanghai) Limited
Halofuginone Lactate pictures 2024-12-13 Halofuginone Lactate
82186-71-8
US $0.00-0.00 / g 10g 98%-100% HPLC 10kg WUHAN FORTUNA CHEMICAL CO., LTD
HALOFUGINONE LACTATE pictures 2024-11-18 HALOFUGINONE LACTATE
82186-71-8
US $55.00-115.00 / mg 99.82% 10g TargetMol Chemicals Inc.

Halofuginone Lactate Spectrum

halofuginonlactat HALOFUGINONE LACTATE 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-quinazolinone GATQERNJKZPJNX-LDXVYITESA-N Athoxanone lactone 2-hydroxypropanoic acid - 7-bromo-6-chloro-3-{3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one (1:1) 82186-71-8 C16H17BrClN3O3xC3H6O3 C16H17BrClN3O3C3H6O3