LOPRAZOLAM
- CAS No.
- 61197-93-1
- Chemical Name:
- LOPRAZOLAM
- Synonyms
- Loprazolam;UTEFBSAVJNEPTR-XMHGGMMESA-N;1H-Imidazo(1,2-A)(1,4)benzodiazepin-1-one, 6-(2-chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-, methanesulphonate
- CBNumber:
- CB52130896
- Molecular Formula:
- C24H25ClN6O6S
- Molecular Weight:
- 561.01
- MDL Number:
- MOL File:
- 61197-93-1.mol
| FDA UNII | 759N8462G8 |
|---|---|
| ATC code | N05CD11 |
LOPRAZOLAM Chemical Properties,Uses,Production
Originator
Avlane,J.A.S.M.,France,1981
Manufacturing Process
1.1 g of methanesulfonic acid were added dropwise to a mixture of 4.6 g of 8- nitro-1,2-dihydro-2-(N-methylpiperazin-1-yl)methylene-6-(o-chlorophenyl)- 1H,4H-imidazo-[1,2-a][1,4]benzodiazepin-1-one in 100 ml of anhydrous methylene chloride and 5 ml of methanol. Dry ether was slowly added until crystals formed on scratching and the solution was allowed to crystallize with further ether being added to complete the crystallization. The pale yellow solid was filtered off, washed with ether and crystallized from methylene chloridemethanol to obtain 5.4 g of 8-nitro-1,2-dihydro-2-(N-methylpiperazin-1- yl)methylene-6-(o-chlorophenyl)-1H,4H-imidazo-[1,2-a][1,4]-benzodiazepin-1- one methanesulfonate melting at 205°C to 210°C.
Therapeutic Function
Tranquilizer