ロプラゾラム 化学特性,用途語,生産方法
Originator
Avlane,J.A.S.M.,France,1981
Manufacturing Process
1.1 g of methanesulfonic acid were added dropwise to a mixture of 4.6 g of 8-
nitro-1,2-dihydro-2-(N-methylpiperazin-1-yl)methylene-6-(o-chlorophenyl)-
1H,4H-imidazo-[1,2-a][1,4]benzodiazepin-1-one in 100 ml of anhydrous
methylene chloride and 5 ml of methanol. Dry ether was slowly added until
crystals formed on scratching and the solution was allowed to crystallize with
further ether being added to complete the crystallization. The pale yellow solid
was filtered off, washed with ether and crystallized from methylene chloridemethanol to obtain 5.4 g of 8-nitro-1,2-dihydro-2-(N-methylpiperazin-1-
yl)methylene-6-(o-chlorophenyl)-1H,4H-imidazo-[1,2-a][1,4]-benzodiazepin-1-
one methanesulfonate melting at 205°C to 210°C.
Therapeutic Function
Tranquilizer
ロプラゾラム 上流と下流の製品情報
原材料
準備製品