ChemicalBook >> CAS DataBase List >>3-Amino-2-chloro-4-methylpyridine
3-Amino-2-chloro-4-methylpyridine
- CAS No.
- 133627-45-9
- Chemical Name:
- 3-Amino-2-chloro-4-methylpyridine
- Synonyms
- 2-CHLORO-4-METHYLPYRIDIN-3-AMINE;2-CHLORO-3-AMINO-4-METHYLPYRIDINE;Capic;TIMTEC-BB SBB010194;3-Amino-2-chloro-4-p;ASINEX-REAG BAS 13794917;2-CHLORO-3-AMINO-4-PICOLINE;3-AMINO-2-CHLORO-4-PICOLINE;2-Chloro-3-Amino-4-Methylpyrid;2-Chlor-4-Methylpyridin-3-Amin
- CBNumber:
- CB5240863
- Molecular Formula:
- C6H7ClN2
- Molecular Weight:
- 142.59
- MDL Number:
- MFCD00673152
- MOL File:
- 133627-45-9.mol
- MSDS File:
- SDS
Last updated:2024-08-21 22:41:43
| Melting point | 65-70 °C |
|---|---|
| Boiling point | 283.3±35.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform, Ethanol |
| pka | 3.22±0.10(Predicted) |
| form | Crystals |
| color | Off White |
| InChI | InChI=1S/C6H7ClN2/c1-4-2-3-9-6(7)5(4)8/h2-3H,8H2,1H3 |
| InChIKey | UOBCYTOUXLAABU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(C)=C1N |
| CAS DataBase Reference | 133627-45-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36-39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
3-Amino-2-chloro-4-methylpyridine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 708135 | 3-Amino-2-chloro-4-methylpyridine 97% | 133627-45-9 | 5g | $66.1 | 2023-06-20 | Buy |
| Sigma-Aldrich | 708135 | 3-Amino-2-chloro-4-methylpyridine 97% | 133627-45-9 | 1g | $24 | 2023-01-07 | Buy |
| TCI Chemical | A1855 | 3-Amino-2-chloro-4-methylpyridine >98.0%(GC)(T) | 133627-45-9 | 5g | $43 | 2024-03-01 | Buy |
| TCI Chemical | A1855 | 3-Amino-2-chloro-4-methylpyridine >98.0%(GC)(T) | 133627-45-9 | 25g | $129 | 2024-03-01 | Buy |
| Alfa Aesar | H26058 | 3-Amino-2-chloro-4-methylpyridine, 97% | 133627-45-9 | 5g | $125 | 2021-12-16 | Buy |
3-Amino-2-chloro-4-methylpyridine Chemical Properties,Uses,Production
Chemical Properties
Off White Crystals
Uses
3-Amino-2-chloro-4-methylpyridine, also known as CAPIC, is a key intermediate in the production of nevirapine, a non-nucleosidic reverse transcriptase inhibitor that has been established to be clinically useful for the treatment of infection by HIV-1.
Preparation
An improved and commercially valuable process is developed by Ge et al. for the scalable synthesis of 2-chloro-3-amino-4-methylpyridine (CAPIC), a key intermediate of Nevirapine. The synthesis was accomplished in four steps, featuring condensation starting from 4,4-dimethoxyl-2-butanone and cyanoacetamide with ammonium acetate and acetic acid as catalysts. Specifically, a stirred solution of NaOH (15.6 g, 0.39 mol) and water (85 g) at 10 ℃ was added, 10% NaClO (96.8 g, 0.13 mol) and ethanol (80 g). 2-Chloro-3-amido-4- methylpyridine 7 (22 g, 0.13 mol) was added to the reaction mixture, stirring for 1 h. The mixture was heated to 60 ℃ and held for 3 h. After ethanol was removed in a vacuum, the mixture was cooled with an ice-water bath for 15–20 min to precipitate solid. Then, the mixture was filtered, washed with water, and dried to give 15.8 g (85.1% yield) of light yellow solid. 14.7 g of the white solid 2 was obtained via recrystallization in toluene.
References
[1] Xin Ge. “A concise synthesis of 2-chloro-3-amino-4-methylpyridine.” Research on Chemical Intermediates 37 6 (2011): 599–604.
3-Amino-2-chloro-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 556)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Guiren Medicine Co.,Ltd | +86-13815020719 +86-13815020719 | guiren_medicine@163.com | China | 133 | 58 |
| shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 30 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Jiangsu Zhongbang Pharmaceutical Co., Ltd. | 025-87151996 | zbsales@chinaredsun.com | CHINA | 32 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9047 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
Related articles
- 3-Amino-2-chloro-4-methylpyridine: Overview and Applications as Drug Intermediates
- 3-Amino-2-chloro-4-methylpyridine is crucial in drug synthesis for HIV/AIDS and breast cancer treatment, with applications in ....
- Mar 29，2024
- The synthesis method of 3-Amino-2-chloro-4-methylpyridine
- 3-Amino-2-chloro-4-methylpyridine is a key intermediate in the production of nevirapine with various synthesis methods.
- Oct 7，2023
View Lastest Price from 3-Amino-2-chloro-4-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-13 | 3-Amino-2-chloro-4-methylpyridine
133627-45-9
|
US $0.00 / Kg/Drum | 1KG | 98%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-10-11 | 2-Chloro-3-amino-4-methyl pyridine
133627-45-9
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-08-27 | 3-Amino-2-chloro-4-methylpyridine
133627-45-9
|
US $80.00-800.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- 3-Amino-2-chloro-4-methylpyridine
133627-45-9
- US $0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Chloro-3-amino-4-methyl pyridine
133627-45-9
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Amino-2-chloro-4-methylpyridine
133627-45-9
- US $80.00-800.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
133627-45-9(3-Amino-2-chloro-4-methylpyridine)Related Search:
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2-CHLORO-4-METHYLPYRIDIN-3-AMINE
2-CHLORO-3-AMINO-4-METHYLPYRIDINE
2-Chlor-4-Methylpyridin-3-Amin
2 Chloro 3 Amino 4 Methyl Pyridene
133627-45-9
133627-45
33627-45-9
C6H7C1N2
C7H4ClF3O4
Halopyridines
Chloropyridines
Building Blocks
C5 to C6
C6
Chemical Synthesis
Halogenated Heterocycles
Heterocyclic Building Blocks
API Intermediate
(intermediate of nevirapine)
Aromatics Compounds
Chloropyridines
Halopyridines
Aromatics
Bases & Related Reagents
Nucleotides
Pyridines, Pyrimidines, Purines and Pteredines
pharmacetical
Amines
Pyridines