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2-Chloro-4-methyl-3-nitropyridine

2-Chloro-4-methyl-3-nitropyridine Structure
2-Chloro-4-methyl-3-nitropyridine structure
CAS No.
23056-39-5
Chemical Name:
2-Chloro-4-methyl-3-nitropyridine
Synonyms
2-Chloro-4-Methyl-3-NP;2-CHLORO-3-NITRO-4-PICOLINE;2-Chloro-3-nitro-4-picoline,98%;2-CHLORO-3-NITRO-4-METHYLPYRIDINE;2-CHLORO-4-METHYL-3-NITROPYRIDINE;3-Nitro-2-chloro-4-methylpyridine;2,Chloro-4-Methyl-3-3-nitropyridine;2-Chloro-4-methyl-3-nitropyridine>PYRIDINE, 2-CHLORO-4-METHYL-3-NITRO-;2-Chloro-4-methyl-3-nitropyridine 98+%
CBNumber:
CB9304053
Molecular Formula:
C6H5ClN2O2
Molecular Weight:
172.57
MDL Number:
MFCD00012347
MOL File:
23056-39-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-11-04 16:47:45
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2-Chloro-4-methyl-3-nitropyridine Properties

Melting point 51-53 °C (lit.)
Boiling point 279.6±35.0 °C(Predicted)
Density 1.406±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka -1.80±0.10(Predicted)
form Powder
color Yellow to beige
Sensitive Hygroscopic
InChI InChI=1S/C6H5ClN2O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3
InChIKey JHARVUVBTAAPLA-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference 23056-39-5(CAS DataBase Reference)
Comptox DTXSID DTXSID30323072
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS07,GHS06
Signal word  Warning
Hazard statements  H315-H319-H335-H302-H312-H331
Precautionary statements  P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P304+P340-P405-P501a
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-21/22
Safety Statements  26-37/39-36/37/39-36
RIDADR  UN2811
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-4-methyl-3-nitropyridine price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 304360 2-Chloro-4-methyl-3-nitropyridine 99% 23056-39-5 1g $108 2023-01-07 Buy
TCI Chemical C2012 2-Chloro-4-methyl-3-nitropyridine >98.0%(GC) 23056-39-5 1g $26 2026-04-30 Buy
TCI Chemical C2012 2-Chloro-4-methyl-3-nitropyridine >98.0%(GC) 23056-39-5 5g $49 2026-04-30 Buy
TRC TRC-C369145-500MG 2-Chloro-4-methyl-3-nitropyridine 23056-39-5 500mg $59 2026-06-03 Buy
TRC TRC-C369145-2G 2-Chloro-4-methyl-3-nitropyridine 23056-39-5 2g $103 2026-06-03 Buy
Product number Packaging Price Buy
304360 1g $108 Buy
C2012 1g $26 Buy
C2012 5g $49 Buy
TRC-C369145-500MG 500mg $59 Buy
TRC-C369145-2G 2g $103 Buy

2-Chloro-4-methyl-3-nitropyridine Chemical Properties, Uses, Production

Chemical Properties

Light yellow Cryst

Uses

2-Chloro-4-methyl-3-nitropyridine is a cyclopropyldipyridodiazepinone derivative for use as non-nucleoside reverse transcriptase inhibitors.

Definition

2-Chloro-4-methyl-3-nitropyridine (2C4M3NP) is a nitropyridine derivative that could form an acceptor fragment of 2-adamantylamino-5-nitropyridine (AANP). This crystal shows a particularly large optical non-linearity. It is observed that the mean C-C (ring) bond distance calculated between the ring carbon atoms of 2C4M3NP is 1.387 Å. In X-ray data of pyridine, the mean C-C (ring) bond distance is 1.394 Å. The C-H bond distances are found to be 1.081 Å. The computed values of C-C (ring) and C-H are slightly higher than that of the experimental value. This is attributed to the substituents present in the pyridine. The C-C-C bond angle where the -Cl and -NO2 group is attached with the middle carbon is more than 120 while the C-C-C bond angle where the -CH3 is substituted is less than 120 in 2C4M3NP. The N-C-CH3 bond angle (116.3。) is less than that of the C-C-CH3 (124.2。) probably due to the weak hydrogen bond formed between the nitrogen and hydrogen of the methyl group[1].
2-Chloro-4-methyl-3-nitropyridine

General Description

Experimental FTIR and FT-Raman spectroscopic analysis of 2-chloro-4-methyl-3-nitropyridine was reported.

Synthesis

2-Hydroxy-4-methyl-3-nitropyridine

21901-18-8

2-Chloro-4-methyl-3-nitropyridine

23056-39-5

General procedure for the synthesis of 2-chloro-4-methyl-3-nitropyridine from 2-keto-3-nitro-4-methylpyridine: 2-keto-3-nitro-4-methylpyridine (13 g, 0.084 mol) was added to 50 mL of phosphorochloridic acid chloride and heated to reflux for 4 hours. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation. The crude product was recrystallized in 50 mL of 75% ethanol solution to give 11 g of white solid product in 75.3% yield. The melting point of the product was 51.7-52.1 °C (ethanol), which is consistent with the values reported in the literature (52.0-52.9 °C) [J.O.C., 1955, 20, 1729-1731].

References

[1] Arjunan, V. , et al. "A comparative study on vibrational, conformational and electronic structure of 2-chloro-4-methyl-3-nitropyridine and 2-chloro-6-methylpyridine." Spectrochimica Acta Part A Molecular & Biomolecular Spectroscopy 92.none(2012):305-317.

2-Chloro-4-methyl-3-nitropyridine synthesis

21901-18-8
23056-39-5
Synthesis of 2-Chloro-4-methyl-3-nitropyridine from 2-Hydroxy-4-methyl-3-nitropyridine

2-Chloro-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Hydroxy-4-methyl-3-nitropyridine 2-Amino-3-nitro-4-picoline 4-Methylpyridin-2-amine

Preparation Products

3-Amino-2-fluoro-4-picoline 3-Fluoropyridine-4-carboxylic acid 2-Chloro-4-methyl-5-nitropyridine 4-bromo-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one N-Cyclopropyl-4-Methyl-3-nitro-2-pyridinaMine
2-Chloro-N-[2-(cyclopropylaMino)-4-Methyl-3-pyridinyl]-3-pyridinecarboxaMide 3-Ethenyl Nevirapine

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2-Chloro-4-methyl-3-nitropyridine Suppliers

Global Suppliers ( 403)
Supplier Tel Email Country ProdList Advantage
Ningbo Fuhe Chemical Co., Ltd. 0574-1806900 18069001216 nbfjj@126.com China 101 58
Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd 13357739131 13357739131 3991044086@qq.com China 712 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44567 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2759 65
Supplier Advantage
Ningbo Fuhe Chemical Co., Ltd. 58
Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65

View Latest Price from 2-Chloro-4-methyl-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-methyl-3-nitropyridine pictures 2026-09-02 2-Chloro-4-methyl-3-nitropyridine
23056-39-5
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-Chloro-4-methyl-3-nitropyridine pictures 2026-08-20 2-Chloro-4-methyl-3-nitropyridine
23056-39-5
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Chloro-4-methyl-3-nitropyridine pictures 2026-06-30 2-Chloro-4-methyl-3-nitropyridine
23056-39-5
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-Chloro-4-methyl-3-nitropyridine Spectrum

2-Chloro-4-methyl-3-nitropyridine(23056-39-5)1HNMR2-Chloro-4-methyl-3-nitropyridine(23056-39-5)Raman2-Chloro-4-methyl-3-nitropyridine(23056-39-5)FT-IR

23056-39-5 (2-Chloro-4-methyl-3-nitropyridine) Related Search:

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2-Chloro-4-picoline Azamethiphos 2-Chloro-3-nitropyridine 2,6-Lutidine 2,4,6-Collidine
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2-Chloro-4-Methyl-3-NP 2-CHLORO-4-METHYL-3-NITROPYRIDINE 2-CHLORO-3-NITRO-4-METHYLPYRIDINE 2-CHLORO-3-NITRO-4-PICOLINE PYRIDINE, 2-CHLORO-4-METHYL-3-NITRO- 2-CHLORO-3-NITRO-4-PICOLINE (2-CHLORO-4-METHYL-3-NITROPYRIDINE) 3-Nitro-2-chloro-4-methylpyridine 2-Chloro-3-nitro-4-picoline,98% 2-Chloro-4-methyl-3-nitropyridine 98+% 2,Chloro-4-Methyl-3-3-nitropyridine 2-Chloro-4-methyl-3-nitropyridine> 2-Chloro-4-methyl-3-nitropyridine ISO 9001：2015 REACH 23056-39-5 C6H5ClN2O2 Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Halopyridines Chloropyridines Building Blocks Non-nucleoside Reverse Transcriptase Amines Aromatics Heterocycles Pyridine Pyridines, Pyrimidines, Purines and Pteredines Pyridine series Heterocyclic Compounds Pyridines Chloropyridines Halopyridines Boronic Acid C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Heterocycle-Pyridine series