AEG 3482
- CAS No.
- 63735-71-7
- Chemical Name:
- AEG 3482
- Synonyms
- AEG 3482;AEG-3482/AEG3482;AEG 3482 >=98% (HPLC);6-PHENYLIMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE;IMIDAZO[2,1-B]-1,3,4-THIADIAZOLE-2-SULFONAMIDE, 6-PHENYL-;6-PHENYL-IMIDAZO[2,1-B][1,3,4]THIADIAZOLE-2-SULFONIC ACID AMIDE
- CBNumber:
- CB52446843
- Molecular Formula:
- C10H8N4O2S2
- Molecular Weight:
- 280.33
- MDL Number:
- MFCD02064987
- MOL File:
- 63735-71-7.mol
| Density | 1.75 |
|---|---|
| storage temp. | Store at RT |
| solubility | DMSO: ≥15mg/mL |
| form | powder |
| pka | 5.05±0.60(Predicted) |
| color | faint yellow to dark yellow |
| FDA UNII | 7EZF1A283N |
AEG 3482 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0264 | AEG 3482 ≥98% (HPLC) | 63735-71-7 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 26213 | AEG 3482 | 63735-71-7 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 26213 | AEG 3482 | 63735-71-7 | 25mg | $381 | 2024-03-01 | Buy |
| Cayman Chemical | 26213 | AEG 3482 | 63735-71-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 26213 | AEG 3482 | 63735-71-7 | 10mg | $169 | 2024-03-01 | Buy |
AEG 3482 Chemical Properties,Uses,Production
Uses
AEG 3482 is an antiapoptotic compound that inhibits Jun Kinase Activity (JNK) and cell death through induced expression of heat shock protein 70. AEG 3482 shows possible use in the treatment of neurological disorders.
Definition
ChEBI: 6-phenyl-2-imidazo[2,1-b][1,3,4]thiadiazolesulfonamide is a member of imidazoles.
Biological Activity
Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M).
References
[1]salehi ah, morris sj, ho wc, etal. , aeg3482 is an antiapoptotic compound that inhibits jun kinase activity and cell death through induced expression of heat shock protein 70. chem biol. 2006 feb;13(2):213-23.
[2] gallo ka. targeting hsp90 to halt neurodegeneration. chem biol. 2006 feb;13(2):115-6.
AEG 3482 Preparation Products And Raw materials
AEG 3482 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7295 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28806 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4010 | 58 |
