ChemicalBook >> CAS DataBase List >>1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
- CAS No.
- 849217-48-7
- Chemical Name:
- 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
- Synonyms
- 1-((4-FL;Cabozantinib impurities4;Cabozantinib Impurity 83;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;1-((4-Fluorophenyl)carbamoyl);FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid
- CBNumber:
- CB52460100
- Molecular Formula:
- C11H10FNO3
- Molecular Weight:
- 223.2
- MDL Number:
- MFCD11226313
- MOL File:
- 849217-48-7.mol
Last updated:2024-12-24 18:06:02
| Melting point | 173.0 to 177.0 °C |
|---|---|
| Boiling point | 475.2±30.0 °C(Predicted) |
| Density | 1.521 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 3.48±0.20(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16) |
| InChIKey | PFMAFXYUHZDKPY-UHFFFAOYSA-N |
| SMILES | C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1 |
| FDA UNII | 8P43N3DM5Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315+H320 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2924.29.9500 | |||||||||
| NFPA 704 |
|
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1083 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid >98.0%(HPLC)(T) | 849217-48-7 | 1g | $105 | 2024-03-01 | Buy |
| TCI Chemical | F1083 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid >98.0%(HPLC)(T) | 849217-48-7 | 5g | $318 | 2024-03-01 | Buy |
| TRC | F632340 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | 849217-48-7 | 10mg | $45 | 2021-12-16 | Buy |
| AK Scientific | W8765 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | 849217-48-7 | 1g | $27 | 2021-12-16 | Buy |
| AK Scientific | W8765 | 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid | 849217-48-7 | 25g | $321 | 2021-12-16 | Buy |
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White powdery substance.
Uses
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.
Synthesis
Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).
Synthesis of 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid from 3-Fluoroaniline and 1,1-Cyclopropanedicarboxylic acid
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
1,1-Cyclopropanedicarbonyl dichloride (9CI)
Cyclopropanecarboxylic acid, 1-(chlorocarbonyl)- (9CI)
METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE
ethyl 1-(4-fluorophenylcarbaMoyl)cyclopropanecarboxylate
1-(ethoxycarbonyl)cyclopropanecarboxylic acid
1of3
Preparation Products
Global( 263)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huanfu Industrial Co.，（Shanghai）Ltd. | +86-18001856580 +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 | admin@hblongbang.com | China | 971 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20262 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 3712 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18949 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
View Lastest Price from 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-14 | 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
|
US $6.00 / KG | 1KG | 99% | 2000KG/MONTH | Hebei Saisier Technology Co., LTD | |
 |
2025-02-14 | 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd | |
 |
2025-02-14 | 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
- US $6.00 / KG
- 99%
- Hebei Saisier Technology Co., LTD
-
- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd
-
- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
849217-48-7(1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid)Related Search:
2-Aminocyclohexanone
4-Aminodiphenylamine
4-Benzothiazolamine (9CI)
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Cabozantinib Malate
4-Aminoveratrole
Cabozantinib Impurity 5
N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
4-chloro-6,7-dimethoxyquinoline
Cabozantinib Impurity EXA
Cabozantinib impurity DX2
Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]-
1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl-
Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)-
Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-
1of4
1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)aMino]carbonyl]-
1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid
InterMediate of Cabozantinib
FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid
1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID
Intermediate2 of Cabozantinib
1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7)
1-((4-FL
1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid
Cabozantinib impurities4
1-((4-Fluorophenyl)carbamoyl)
Cabozantinib Impurity 83
849217-48-7
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849217-48-7