ChemicalBook >제품 카탈로그 >1-(4-플루오로페닐카르바모일)시클로프로판카르복실산

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 구조식 이미지

카스 번호:: 849217-48-7

한글명:: 1-(4-플루오로페닐카르바모일)시클로프로판카르복실산

동의어(한글):: 1-(4-플루오로페닐카르바모일)시클로프로판카르복실산

상품명:: 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

동의어(영문):: 1-((4-FL;Cabozantinib impurities4;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid;1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid;1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid

CBNumber:: CB52460100

분자식:: C11H10FNO3

포뮬러 무게:: 223.2

MOL 파일:: 849217-48-7.mol

속성

안전

용도

공급 업체 241

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 속성

녹는점: 173.0 to 177.0 °C

끓는 점: 475.2±30.0 °C(Predicted)

밀도: 1.521

저장 조건: Sealed in dry,Room Temperature

용해도: 메탄올에 용해됨

물리적 상태: powder to crystal

산도 계수 (pKa): 3.48±0.20(Predicted)

색상: 흰색에서 거의 흰색

InChI: InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)

InChIKey: PFMAFXYUHZDKPY-UHFFFAOYSA-N

SMILES: C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1

안전

위험 및 안전 성명

HS 번호	2924.29.9500

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P332+P313	피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

NFPA 704

	0
2		0

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 C화학적 특성, 용도, 생산

화학적 성질

White powdery substance.

용도

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.

Synthesis

Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 준비 용품 및 원자재

원자재

1,1-사이클로프로판디카보닐디클로라이드(9CI) 시클로프로판카르복실산,1-(클로로카르보닐)-(9CI) 메틸1-[(4-플루오로페닐)카르바모일]시클로프로판카르복실레이트 에틸1-((4-플루오로페닐)카르바모일)시클로프로판카르복실레이트 1-(에톡시카르보닐)시클로프로판카르복실산 1,1-사이클로프로판디카르복실산모노메틸에스테르 1,1-Cyclopropanedicarboxylic acid dimethyl ester 플로로아닐린 1,1-Cyclopropanedicarboxylic acid 4-플로로아닐린 Diethyl 1,1-cyclopropanedicarboxylate

준비 용품

카보잔티닙

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 공급 업체

글로벌( 241)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580 +86-18001856580	2415195517@qq.com	China	43	58
Hebei Longbang Technology Co., LTD	+86-18032476855 +86-18032476855	admin@hblongbang.com	China	983	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20374	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-18034520335	admin@hbsaisier.cn	China	989	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	16221	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Shandonghaohong biotechnology Co.,ltd.	0635-6175299 13961496334	sale@inyelchem.com	CHINA	44	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58

1-(4-플루오로페닐카르바모일)시클로프로판카르복실산 관련 검색:

2-Aminocyclohexanone 4-Aminodiphenylamine 4-Benzothiazolamine (9CI) 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Cabozantinib Malate 4-Aminoveratrole Cabozantinib Impurity 5 N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide 4-chloro-6,7-dimethoxyquinoline Cabozantinib Impurity EXA Cabozantinib impurity DX2 Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]- 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib impurity 1DYH Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-