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Acotiamide hydrochloride trihydrate

Acotiamide hydrochloride trihydrate Structure
Acotiamide hydrochloride trihydrate structure
CAS No.
773092-05-0
Chemical Name:
Acotiamide hydrochloride trihydrate
Synonyms
Acotiamide hydrochloride hydrate;Acotiamide HCl;Ym-443;Acotiae;Z-338 HCl;YM-443 HCl;Unii-nmw7447A9a;Acofide trihydrate;YM-443;ACOTIAMIDE HCL;Acotiamide trihydrate
CBNumber:
CB52493115
Molecular Formula:
C21H31ClN4O5S
Molecular Weight:
487.013
MDL Number:
MFCD28101055
MOL File:
773092-05-0.mol
MSDS File:
SDS
Last updated:2024-11-14 14:09:35
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Acotiamide hydrochloride trihydrate Properties

Melting point 193-195o C
storage temp. 2-8°C
solubility Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly) Methanol (Slightly)
form Solid
color Pale Yellow
FDA UNII NMW7447A9A

Acotiamide hydrochloride trihydrate price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A190240 AcofideTrihydrate 773092-05-0 1g $210 2021-12-16 Buy
Biosynth Carbosynth FA137643 Acotiamide HCl hydrate 773092-05-0 500mg $230 2021-12-16 Buy
Biosynth Carbosynth FA137643 Acotiamide HCl hydrate 773092-05-0 1g $350 2021-12-16 Buy
Biosynth Carbosynth FA137643 Acotiamide HCl hydrate 773092-05-0 2g $440 2021-12-16 Buy
ChemScene CS-0020306 Acotiamide(monohydrochloridetrihydrate) 99.28% 773092-05-0 100mg $50 2021-12-16 Buy
Product number Packaging Price Buy
A190240 1g $210 Buy
FA137643 500mg $230 Buy
FA137643 1g $350 Buy
FA137643 2g $440 Buy
CS-0020306 100mg $50 Buy

Acotiamide hydrochloride trihydrate Chemical Properties,Uses,Production

Description

In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.

Originator

Zeria Pharmaceutical (Japan)

Uses

Acofide Trihydrate is a gastrointestinal prokinectic agent used in the treatment of functional malnutrition. A tablet for the treatment of functional dyspepsia.

brand name

Acofide

Synthesis

Commercial 3,4,5-trimethoxybenzoic acid was first converted to the corresponding acid chloride, which was isolated by co-distillation with hexane. In refluxing dichloroethane (DCE), the acid chloride was coupled with the commercially available thiazole amine to give the desired amidothiazole in 89% yield. From this intermediate, amide linkage, selective demethylation of the 2-methoxy group, salt formation, and recrystallization were accomplished in the following sequence: the thiazole ester was reacted with N,N-diisopropyl ethylenediamine in DMA at elevated temperatures. Upon cooling, the mixture was dissolved in n-butanol and washed with aqueous sodium hydroxide. Subsequent treatment with HCl gas in isopropanol gave the corresponding HCl salt as crystals that could be collected by filtration. The product obtained was further crystallized from 4:1 isopropanol and water to give the desired product acotimide (I) as the hydrochloride trihydrate in 71% yield.

Synthesis_773092-05-0

Acotiamide hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Acotiamide hydrochloride trihydrate Suppliers

Global( 234)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Kingfiner Technology Development Co.Ltd 		+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3010 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9214 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29884 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691 yklbiotech@163.com CHINA 296 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +8615064153060 sales01@jndxj.com China 291 58
Supplier Advantage
Hebei Kingfiner Technology Development Co.Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Lianyungang happen teng technology co., LTD 		58
career henan chemical co 		58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		58
Anhui Dexinjia Biopharm Co., Ltd 		58

View Lastest Price from Acotiamide hydrochloride trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Acotiamide monohydrochloride trihydrate pictures 2024-11-14 Acotiamide monohydrochloride trihydrate
773092-05-0
 US $35.00 / mg 99.48% 10g TargetMol Chemicals Inc.
Acotiamide hydrochloride trihydrate pictures 2024-10-25 Acotiamide hydrochloride trihydrate
773092-05-0
 US $0.00 / kg 1kg 99% HPLC 500kg/week Hebei Yanxi Chemical Co., Ltd.
Acotiamide hydrochloride trihydrate pictures 2024-06-12 Acotiamide hydrochloride trihydrate
773092-05-0
 US $0.00-0.00 / kg 1kg 99% 500000kg Hebei Kingfiner Technology Development Co.Ltd

Acotiamide hydrochloride trihydrate Spectrum

Acotiamide hydrochloride trihydrate(773092-05-0)1HNMR

773092-05-0(Acotiamide hydrochloride trihydrate)Related Search:

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Aprepitant Acotiamide Hydrochloride Hydrate

1of3

N-(2-(Diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxyamide monohydrochloride trihydrate Unii-nmw7447A9a Ym-443 AcotiaMide hydrochloride trihydrate Acotiae 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3) Acofide trihydrate N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino] Acotiamide HCl Hydrate N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide monohydrochloride trihydrate Acotiamide HCl Trihydrate N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydro N-[2-[DI(PROPAN-2-YL)AMINO]ETHYL]-2-[(2-HYDROXY-4,5-DIMETHOXYBENZOYL)AMINO]-1,3-THIAZOLE-4-CARBOXAMIDE YM-443;ACOTIAMIDE HCL Acotamine hydrochloride trihydrate N-[2-(Diisopropylamino)ethyl]-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide Hydrochloride Trihydrate N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide,trihydrate,hydrochloride Acotiamide trihydrate AcotiaMide hydrochloride hydrate CAS 773092-05-0 Hot sale top quality Acotiamide hydrochloride hydrate with factory price High Quality Acotiamide hydrochloride hydrate Acotiamide hydrochloride hydrate Acotiamide HCl 773092-05-0 Bulk AcotiaMide hydrochloride hydrate CAS NO.773092-05-0 Acotiamide hydrochlorid Acorticoid hydrochloride N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate (1:1:3) YM-443 HCl Z-338 HCl Acetylformamide hydrochloride trihydrate Acofide trihydrate,Acotiamide hydrochloride trihydrate,Acotiamide hydrochloride hydrate Acotiamide hydrochloride trihydrate (YM443 TIANFUCHEM--773092-05-0--Ym-443 factory price Acotiamide hydrochloride hydrate Acotiamide HCl 4-((4-((2-(diisopropylamino)ethyl)carbamoyl)thiazol-2-yl)carbamoyl)-5-hydroxyphthalic acid hydrochloride trihydrate (Acotiamide HCl Trihydrate) Acotamine hydrochloride trihydrate compound 773092-05-0 C21H30N4O5SHCl3H2O C21H37ClN4O8S C21H31ClN4O5S C21H30N4O5SClH3H2O C21H30N4O5SClH Inhibitors API 773092-05-0