Fostamatinib

Fostamatinib Properties

Melting point	214° - 217°C
Boiling point	814.2±75.0 °C(Predicted)
Density	1.496
storage temp.	-20°C, Hygroscopic
solubility	DMSO (Slightly), Methanol (Slightly)
pka	1.70±0.10(Predicted)
form	Solid
color	White to Off-White
Stability	Hygroscopic
NCI Dictionary of Cancer Terms	fostamatinib disodium
FDA UNII	SQ8A3S5101
NCI Drug Dictionary	fostamatinib disodium
ATC code	B02BX09

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

Fostamatinib price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	474099	Fostamatinib	901119-35-5	100mg	$1423	2021-12-16	Buy
Matrix Scientific	125210	Fostamatinib 95+%	901119-35-5	1g	$3036	2021-12-16	Buy
ChemScene	CS-2152	Fostamatinib 99.20%	901119-35-5	100mg	$708	2021-12-16	Buy
ApexBio Technology	B2284	Fostamatinib(R788)	901119-35-5	100mg	$713	2021-12-16	Buy
AK Scientific	X2110	Fostamatinibdisodium	901119-35-5	1g	$4148	2021-12-16	Buy

Product number	Packaging	Price	Buy
474099	100mg	$1423	Buy
125210	1g	$3036	Buy
CS-2152	100mg	$708	Buy
B2284	100mg	$713	Buy
X2110	1g	$4148	Buy

Fostamatinib Chemical Properties,Uses,Production

Binding Mode

As shown in the co-crystal structure of tamatinib-SYK (Fig. 1), the aminopyrimidine moiety forms two hydrogen bonds with Ala451 of the hinge region. In addition, there is an atypical hydrogen bond (CH...O=C) between CH at 6 and amide carbonyl of Glu449 (Fig. 2).
Figure 1. Co-crystal structure of tamatinib (parent drug of fostamatinib) with SYK (PDB ID: 3FQS). Figure 2. Summary of tamatinib–SYK interactions based on their co-crystal structure

Uses

Fostamatinib can be used to treat cancers that have acquired resistance to kinase inhibitors.

Indications

Fostamatinib is an FDA-approved first-in-class spleen tyrosine kinase (SYK) inhibitor, specifically indicated for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have not responded adequately to prior therapies.

brand name

Tavalisse

General Description

Class: non-receptor tyrosine kinase; Treatment: ITP; Other name: R788; Oral bioavailability = 100% (prodrug); Elimination half-life = 15 h (tamatinib); Protein binding = 98.3%

Biological Activity

fostamatinib is a small molecule inhibitor of spleen tyrosine kinase (syk) with ic50 value of 41nm [1].fostamatinib is an orally bioavailable prodrug of r406. it is developed for the treatment of autoimmune diseases. the effective metabolite of fostamatinib, r406, is an atp-competitive inhibitor of syk with ki value of 30nm. r406 also inhibits the activity of other kinases including flt3, lyn (ic50=63nm) and lck (ic50=37nm). it is found that r406 inhibits both bcr and fcr mediated responses in vitro. besides that, r406 also shows effects in other cells types and signalling pathways. in the in vivo assay, fostamatinib shows to be highly active to inhibit fcr-mediated signaling in various animal models of allergy, autoimmunity and inflammation. moreover, fostamatinib also exerts efficacy in sle animal models. treatment of fostamatinib suppresses the established renal and skin disease and reduces lymphadenopathy in the mrl/lpr strain [1].

target

Primary target: SYK

References

[1] mcadoo s p, tam f w k. fostamatinib disodium. drugs of the future, 2011, 36(4): 273.

Fostamatinib synthesis

Synthesis of Fostamatinib from Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate

Fostamatinib Preparation Products And Raw materials

Raw materials

R-406 Ditert-butyl [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate

Preparation Products

Fostamatinib Suppliers

Global( 172)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5978	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9314	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
TianYuan Pharmaceutical CO.,LTD	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Wuhan Fortuna Chemical Co., Ltd	58
Baoji Guokang Bio-Technology Co., Ltd.	58

View Lastest Price from Fostamatinib manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-25	Fostamatinib (R788) 901119-35-5	US $0.00-0.00 / g	10g	99% HPLC	1000kg	HangZhou RunYan Pharma Technology Co.,LTD.
2024-11-22	Fostamatinib 901119-35-5	US $0.00 / g	1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-19	Fostamatinib 901119-35-5	US $36.00-81.00 / mg		98.3%	10g	TargetMol Chemicals Inc.

Fostamatinib (R788)
901119-35-5
US $0.00-0.00 / g
99% HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

Fostamatinib
901119-35-5
US $0.00 / g
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Fostamatinib
901119-35-5
US $36.00-81.00 / mg
98.3%
TargetMol Chemicals Inc.

Fostamatinib Spectrum

Fostamatinib(901119-35-5)¹HNMR

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Fostamatinib FostaMatinib DisodiuM FostaMatinib (R788) R788 NSC-745942 R-935788 R7935788 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate R788, >=99% FOSTAMATINIB (R788);R788 R788 5MG Tavalisse) {[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]py rimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H- pyrido[3,2-b][1,4]oxazin-4-yl]methoxy}phosphonic acid sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl phosphate Fostamatinib USP/EP/BP 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]- R788 free base R788 (Fostamatinib, FosD, tamatinib fosdium) CS-883 R 788;R-788;R788 [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate RT788 Blessing him Fostatinib 13C,2H3]-Fostamatinib (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate?, Fostamatinib (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate 901119-35-5 C23H26FN6O9P Inhibitors API