Hydroxy(2-naphthyl)Methanephosphonic Acid
- CAS No.
- 132541-52-7
- Chemical Name:
- Hydroxy(2-naphthyl)Methanephosphonic Acid
- Synonyms
- Hydroxy(2-naphthyl)Methanephosphonic Acid;P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid;Phosphonic acid, P-(hydroxy-2-naphthalenylmethyl)-;Inhibitor,HNMPA,serine autophosphorylation,tyrosine autophosphorylation,tyrosine kinase,Insulin Receptor,inhibit
- CBNumber:
- CB52545214
- Molecular Formula:
- C11H11O4P
- Molecular Weight:
- 238.18
- MDL Number:
- MFCD27943631
- MOL File:
- 132541-52-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
Hydroxy(2-naphthyl)Methanephosphonic Acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J63913 | (Hydroxy-2-naphthylmethyl)phosphonic acid 98% | 132541-52-7 | 5mg | $126.65 | 2024-03-01 | Buy |
| Alfa Aesar | J63913 | (Hydroxy-2-naphthylmethyl)phosphonic acid 98% | 132541-52-7 | 25mg | $615 | 2023-06-20 | Buy |
| Cayman Chemical | 15543 | HNMPA ≥95% | 132541-52-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15543 | HNMPA ≥95% | 132541-52-7 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 15543 | HNMPA ≥95% | 132541-52-7 | 10mg | $139 | 2024-03-01 | Buy |
Hydroxy(2-naphthyl)Methanephosphonic Acid Chemical Properties,Uses,Production
Description
HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro.
Uses
A selective insulin receptor tyrosine kinase inhibitor
Uses
Insulin receptor tyrosine kinase (IRTK) inhibitor.
References
[1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9.
[2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95.
Hydroxy(2-naphthyl)Methanephosphonic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
Hydroxy(2-naphthyl)Methanephosphonic Acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56057 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |