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Refametinib

Refametinib structure

CAS No.: 923032-37-5

Chemical Name:: Refametinib

Synonyms: RDEA119;CS-2434;BAY-869766;BAY 8697661;RefaMetinib;RDEA119 USP/EP/BP;REFAMETINIB(RDEA119);RDEA-119 (BAY-869766);Acrylamide Impurity 13;RefaMetinib/BAY 8697661

CBNumber:: CB52561494

Molecular Formula:: C19H20F3IN2O5S

Molecular Weight:: 572.34

MDL Number:: MFCD18633256

MOL File:: 923032-37-5.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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Refametinib Properties

Boiling point	566.9±60.0 °C(Predicted)
Density	1.82±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form	Powder
pka	15.54±0.20(Predicted)
color	White to yellow
NCI Dictionary of Cancer Terms	lorlatinib
FDA UNII	JPX07AFM0N
NCI Drug Dictionary	lorlatinib
ATC code	L01ED05

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H372-H361
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501
HS Code	2935909099

Refametinib price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16997	Refametinib ≥95%	923032-37-5	1mg	$38	2024-03-01	Buy
Cayman Chemical	16997	Refametinib ≥95%	923032-37-5	5mg	$111	2024-03-01	Buy
Cayman Chemical	16997	Refametinib ≥95%	923032-37-5	10mg	$166	2024-03-01	Buy
Cayman Chemical	16997	Refametinib ≥95%	923032-37-5	50mg	$547	2024-03-01	Buy
Usbiological	464562	Refametinib	923032-37-5	1mg	$312	2021-12-16	Buy

Product number	Packaging	Price	Buy
16997	1mg	$38	Buy
16997	5mg	$111	Buy
16997	10mg	$166	Buy
16997	50mg	$547	Buy
464562	1mg	$312	Buy

Refametinib Chemical Properties,Uses,Production

Description

Lorlatinib (PF-06463922, Pfizer Oncology, Groton, CT, USA) is an oral TKI that targets both ALK and ROS1 with high affinity and good CNS penetration [91].

Uses

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2. Potent MEK inhibitor.

Clinical Use

Lorlatinib is the sole third-generation ALK inhibitor at this time; it is approved for ALK-positive NSCLC patients who progressed on at least two ALK inhibitors with one being crizotinib or who progressed on alectinib or ceritinib if either is used in the frontline setting.

in vivo

Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, highly selective inhibitor of MEK1/2, which is active in human tumor xenograft models and is well tolerated within the therapeutic exposure range in animals^[1].

target

MEK1

IC 50

MEK1: 19 nM (IC₅₀); MEK2: 47 nM (IC₅₀)

References

[1] iverson c, larson g, lai c, et al. rdea119/bay 869766: a potent, selective, allosteric inhibitor of mek1/2 for the treatment of cancer. cancer research, 2009, 69(17): 6839-6847.

Refametinib Preparation Products And Raw materials

Raw materials

Preparation Products

Refametinib Suppliers

Global( 117)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Chengdu Feibo Pharm Technology Co., Ltd	+86 028-84641798 15982321820	abby@arkpharm.com	China	10922	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9304	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-18712993135	sales01@tairunfaz.com	China	8051	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Chengdu Feibo Pharm Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hebei Fengjia New Material Co., Ltd	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from Refametinib manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Refametinib 923032-37-5	US $33.00-73.00 / mg		99.84%	10g	TargetMol Chemicals Inc.
2021-07-13	Refametinib 923032-37-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Refametinib 923032-37-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Refametinib
923032-37-5
US $33.00-73.00 / mg
99.84%
TargetMol Chemicals Inc.

Refametinib
923032-37-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Refametinib
923032-37-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Refametinib Spectrum

RDEA119(923032-37-5)¹HNMR

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RDEA119 BAY-869766 RefaMetinib RDEA-119 (BAY-869766) BAY 8697661 RefaMetinib/BAY 8697661 N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide REFAMETINIB(RDEA119) BAY 869766;BAY 86-97661;RDEA119 Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]- RDEA119 USP/EP/BP Refametinib S enantiomer CS-2434 BAY 869766; BAY 86-9766 Refametinib (BAY86-9766) N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2s)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide Acrylamide Impurity 13 Refametinib, 10 mM in DMSO 923032-37-5 C19H20F3IN2O5S Inhibitors