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WAY-600

CAS No.
1062159-35-6
Chemical Name:
WAY-600
Synonyms
WAY-600;WAY-600;WAY 600;WAY-600 USP/EP/BP;6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine;4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine;6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine;1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-
CBNumber:
CB52561500
Molecular Formula:
C28H30N8O
Molecular Weight:
494.59
MDL Number:
MFCD22419019
MOL File:
1062159-35-6.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

WAY-600 Properties

Density 1.43
storage temp. Store at -20°C
solubility Soluble in DMSO > 10 mM
form Powder
pka 16.08±0.30(Predicted)
color White to off-white

WAY-600 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29214 WAY-600 1062159-35-6 1mg $89 2024-03-01 Buy
Cayman Chemical 29214 WAY-600 1062159-35-6 10mg $437 2024-03-01 Buy
Cayman Chemical 29214 WAY-600 1062159-35-6 5mg $330 2024-03-01 Buy
ApexBio Technology B1641 WAY-600 1062159-35-6 1unit $28 2021-12-16 Buy
American Custom Chemicals Corporation API0010224 WAY-600 95.00% 1062159-35-6 5MG $459.8 2021-12-16 Buy
Product number Packaging Price Buy
29214 1mg $89 Buy
29214 10mg $437 Buy
29214 5mg $330 Buy
B1641 1unit $28 Buy
API0010224 5MG $459.8 Buy

WAY-600 Chemical Properties,Uses,Production

Biological Activity

WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with IC50 of 9 nM for recombinant mTOR enzyme. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.

in vitro

WAY-600 decreased exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically . Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. It dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association ) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).

in vivo

Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, po daily).

target

mTOR

9 nM (IC 50 )

mTORC1

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mTORC2

PI3K alpha

1.96 μM (IC 50 )

PI3K gamma

8.45 μM (IC 50 )

WAY-600 Preparation Products And Raw materials

Raw materials

Preparation Products

WAY-600 Suppliers

Global( 89)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5221 58

View Lastest Price from WAY-600 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WAY-600 pictures 2024-11-19 WAY-600
1062159-35-6
US $32.00-98.00 / mg 99.63% 10g TargetMol Chemicals Inc.
  • WAY-600 pictures
  • WAY-600
    1062159-35-6
  • US $32.00-98.00 / mg
  • 99.63%
  • TargetMol Chemicals Inc.

WAY-600 Spectrum

WAY-600 6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine 6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine WAY-600;WAY 600 4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine 1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]- WAY-600 USP/EP/BP 4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine 1062159-35-6 C28H30N8O Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR