PELITINIB
- CAS No.
- 257933-82-7
- Chemical Name:
- PELITINIB
- Synonyms
- Pelitinib(EKB-569);PELITINIB;WAY172569;WAY 172569;WAY-172569;WAY-EKB 569;Pelitinib, >=98%;EKB-569 Pelitinib;257933-82-7 PELITINIB;PELITINIB (EKB-569;WAY-EKB 569)
- CBNumber:
- CB81011748
- Molecular Formula:
- C24H23ClFN5O2
- Molecular Weight:
- 467.92
- MDL Number:
- MFCD09837868
- MOL File:
- 257933-82-7.mol
- MSDS File:
- SDS
Melting point | 173-178°C |
---|---|
Boiling point | 655.5±55.0 °C(Predicted) |
Density | 1.34 |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO: soluble5mg/mL, clear (warmed) |
form | powder |
pka | 12.23±0.43(Predicted) |
color | white to beige |
NCI Dictionary of Cancer Terms | pelitinib |
FDA UNII | X5DWL380Z6 |
NCI Drug Dictionary | pelitinib |
PELITINIB price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PZ0197 | Pelitinib ≥98% (HPLC) | 257933-82-7 | 5mg | $149 | 2024-03-01 | Buy |
Sigma-Aldrich | PZ0197 | Pelitinib ≥98% (HPLC) | 257933-82-7 | 25mg | $594 | 2024-03-01 | Buy |
TCI Chemical | P2529 | Pelitinib >97.0%(HPLC) | 257933-82-7 | 25mg | $143 | 2024-03-01 | Buy |
TCI Chemical | P2529 | Pelitinib >97.0%(HPLC) | 257933-82-7 | 100mg | $389 | 2024-03-01 | Buy |
Cayman Chemical | 15627 | Pelitinib ≥98% | 257933-82-7 | 1mg | $44 | 2024-03-01 | Buy |
PELITINIB Chemical Properties,Uses,Production
Description
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).
Chemical Properties
Off-White Solid
Uses
Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
Uses
An EGFR inhibitor
Uses
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
Definition
ChEBI: Pelitinib is an aminoquinoline, a nitrile, a monocarboxylic acid amide and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.
target
EGFR
storage
Store at -20°C
References
[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.
[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.
PELITINIB Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9321 | 58 |
View Lastest Price from PELITINIB manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2021-07-13 | Pelitinib
257933-82-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
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2021-07-10 | Pelitinib
257933-82-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
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2019-07-10 | PELITINIB
257933-82-7
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |