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CAY10505

CAY10505 Structure
CAY10505 structure
CAS No.
328960-84-5
Chemical Name:
CAY10505
Synonyms
5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-;(5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
CBNumber:
CB52590416
Molecular Formula:
C14H8FNO3S
Molecular Weight:
289.28
MDL Number:
MFCD18382079
MOL File:
328960-84-5.mol
Last updated:2023-06-08 09:03:08
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CAY10505 Properties

Density 1.466±0.06 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
form A crystalline solid
pka 6.21±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

CAY10505 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009078 CAY10505 ≥98% 328960-84-5 5mg $37 2024-03-01 Buy
Cayman Chemical 10009078 CAY10505 ≥98% 328960-84-5 10mg $68 2024-03-01 Buy
Cayman Chemical 10009078 CAY10505 ≥98% 328960-84-5 25mg $161 2024-03-01 Buy
Cayman Chemical 10009078 CAY10505 ≥98% 328960-84-5 50mg $283 2024-03-01 Buy
Biosynth Carbosynth FC137603 CAY10505 328960-84-5 25mg $385 2021-12-16 Buy
Product number Packaging Price Buy
10009078 5mg $37 Buy
10009078 10mg $68 Buy
10009078 25mg $161 Buy
10009078 50mg $283 Buy
FC137603 25mg $385 Buy

CAY10505 Chemical Properties,Uses,Production

Description

Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).1 Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).1 Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.1

References

1. Pomel, V., Klicic, J., Covini, D., et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ J. Med. Chem. 49(13),3857-3871(2006).

CAY10505 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10505 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 29778 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5595 58
Carbosynth -- sales@carbosynth.com United Kingdom 6018 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Carbosynth 58
(5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione 5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione 2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]- 328960-84-5