NVP-AEW541 (hydrochloride)
- CAS No.
- 2320261-63-8
- Chemical Name:
- NVP-AEW541 (hydrochloride)
- Synonyms
- AEW541 HCl;NVP-AEW541 (hydrochloride);7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine,dihydrochloride
- CBNumber:
- CB52591882
- Molecular Formula:
- C27H30ClN5O
- Molecular Weight:
- 476.02
- MDL Number:
- MOL File:
- 2320261-63-8.mol
Last updated:2023-04-23 13:52:06
NVP-AEW541 (hydrochloride) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 500μg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 1mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 5mg | $437 | 2024-03-01 | Buy |
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 10mg | $765 | 2024-03-01 | Buy |
NVP-AEW541 (hydrochloride) Chemical Properties,Uses,Production
Description
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.
NVP-AEW541 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-AEW541 (hydrochloride) Suppliers
Global( 14)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
NVP-AEW541 (hydrochloride)
7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine,dihydrochloride
AEW541 HCl
2320261-63-8