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ChemicalBook >> NVP-AEW541 (hydrochloride)

NVP-AEW541 (hydrochloride)

NVP-AEW541 (hydrochloride) price.
  • $81 - $765
  • Product name: NVP-AEW541 (hydrochloride)
  • CAS: 2320261-63-8
  • MF: C27H30ClN5O
  • MW: 476.02
  • EINECS:
  • MDL Number:
  • Synonyms:NVP-AEW541 (hydrochloride);7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine,dihydrochloride;AEW541 HCl
4 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerCayman Chemical
  • Product number13641
  • Product descriptionNVP-AEW541 (hydrochloride) ≥98%
  • Packaging500μg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13641
  • Product descriptionNVP-AEW541 (hydrochloride) ≥98%
  • Packaging1mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13641
  • Product descriptionNVP-AEW541 (hydrochloride) ≥98%
  • Packaging5mg
  • Price$437
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13641
  • Product descriptionNVP-AEW541 (hydrochloride) ≥98%
  • Packaging10mg
  • Price$765
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 13641 NVP-AEW541 (hydrochloride) ≥98% 500μg $81 2024-03-01 Buy
Cayman Chemical 13641 NVP-AEW541 (hydrochloride) ≥98% 1mg $117 2024-03-01 Buy
Cayman Chemical 13641 NVP-AEW541 (hydrochloride) ≥98% 5mg $437 2024-03-01 Buy
Cayman Chemical 13641 NVP-AEW541 (hydrochloride) ≥98% 10mg $765 2024-03-01 Buy

Properties

solubility :Ethanol: 0.3 mg/ml; PBS (pH 7.2): 2.5 mg/ml
form :A crystalline solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.