ChemicalBook >> CAS DataBase List >>3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
- CAS No.
- 1022150-12-4
- Chemical Name:
- 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
- Synonyms
- (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;ibrutinib N-1;3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride;Ilutinib impurity 18;Ibrutinib Impurity 18;4-d]pyriMidin-4-ylaMine;Ibrutinib intermediate 1;Ibrutinib intermeidate N-1;Btk inhibitor 1 (R enantioMer)
- CBNumber:
- CB52623905
- Molecular Formula:
- C22H22N6O
- Molecular Weight:
- 386.45
- MDL Number:
- MFCD20482137
- MOL File:
- 1022150-12-4.mol
- MSDS File:
- SDS
Last updated:2024-04-29 14:28:21
Melting point | 133-136oC |
---|---|
Boiling point | 626.3±55.0 °C(Predicted) |
Density | 1.39±0.1 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 9.00±0.10(Predicted) |
form | Solid |
color | White to Pale Yellow |
FDA UNII | NR6GN4MC2R |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | P318770 | (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1022150-12-4 | 10g | $845 | 2021-12-16 | Buy |
TRC | P318770 | (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1022150-12-4 | 5g | $545 | 2021-12-16 | Buy |
Matrix Scientific | 132822 | 3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 97% | 1022150-12-4 | 5g | $864 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0292889 | 3-(4-PHENOXY-PHENYL)-1-PIPERIDIN-3-YL-1H-PYRAZOLO-[3,4-D]PYRIMIDIN-4-YLAMINE 95.00% | 1022150-12-4 | 5G | $1246.25 | 2021-12-16 | Buy |
ChemScene | CS-2435 | IBT6A 99.47% | 1022150-12-4 | 50mg | $1800 | 2021-12-16 | Buy |
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Chemical Properties,Uses,Production
Description
IBT6A is a Btk kinase inhibitor. This compound is a precurser for the manufacture of ibrutinib.
Uses
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate used to prepare pyrazolo-pyrimidine compounds as inhibitors of Bruton''s tyrosine kinase. It is also an intermediate for Ibrutinib (I124970) derivatives.
![330786-24-8](/CAS/20150408/GIF/330786-24-8.gif)
![143900-44-1](/CAS/GIF/143900-44-1.gif)
![1022150-12-4](/CAS/GIF/1022150-12-4.gif)
Synthesis of 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine from 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine and (S)-1-Boc-3-hydroxypiperidine
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 258)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
View Lastest Price from 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-15 | 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
1022150-12-4
|
US $20.00-10.00 / kg | 25kg | 99% | 200ton | Hebei Yanxi Chemical Co., Ltd. | |
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2024-05-09 | (R)-3-(4-phenoxyphenyl)-1-(pi-peridin-3-yl)-1H-pyrazolo-[3,4-d]pyrimidin-4-amine
1022150-12-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | |
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2024-04-29 | 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
1022150-12-4
|
US $10.00-3.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
1022150-12-4
- US $20.00-10.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.
-
- (R)-3-(4-phenoxyphenyl)-1-(pi-peridin-3-yl)-1H-pyrazolo-[3,4-d]pyrimidin-4-amine
1022150-12-4
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
1022150-12-4
- US $10.00-3.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
1022150-12-4(3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine)Related Search:
3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Btk inhibitor 1 (R enantioMer hydrochloride)
Ibrutinib Impurity 21
Ibrutinib Impurity 10
Imatinib Impurity 72
(S)-Ibrutinib
Chidamide
(R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone
Esmolol Impurity 2 HCl
Cilastatin
1of4
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
3-(4-Phenoxy-phenyl)-1-(R)-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
Btk inhibitor 1 (R enantioMer)
Ibrutinib intermeidate N-1
3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyriMidin-4-aMine
3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-Pyrazolo[3,4-d]pyrimidin-4-amine
Ibrutinib (PCI-32765) Intermediates
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine(Btk inhibitor 1 R enantiomer)
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-4-Amino-3-(4-phenoxyphenyl)-1-(3-piperidyl)-1H-pyrazolo[3,4-d]pyrimidine
Ibrutinib Impurity 18
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 1022150-12-4
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1022150-12-4
3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
Ibrutinib N-1 (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine
(S)-Ibrutinib N-Desacryloyl Impurity
(R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1 H- pyrazole [3,4- d] pyrimidine-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-
Ibrutinib N-Desacryloyl Impurity
3- (4-phenoxy-phenyl) -1-piperidine-3-yl-1H-pyrazolium [3, 4-D] pyrimidin-4-ylamine
Ibrutinib intermediate 1
3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3
4-d]pyriMidin-4-ylaMine
(R)-3-(4-Phenoxyphenyl)-1
-(piperidin-3-yl)pyrazolo [3,4-D]pyrimidin-4-ylamine
3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-...
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMi
TIANFUCHEM--1022150-12-4---3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine
ibrutinib N-1
3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
3-(4-phenoxypheny)1-((3R)-3-pipeidinyl)-1H-pyrazolo[3.4-dleyrimidin-4-amine
Ilutinib impurity 18
(R) -3- (4-phenoxyphenyl) -1- (piperidin-3-yl) pyrazolo [3,4-D] pyrimidin-4-amine
1022150-12-4
022150-12-4
Ibrutinib
Intermediates