(+/-)-THIOPENTAL
- CAS No.
- 76-75-5
- Chemical Name:
- (+/-)-THIOPENTAL
- Synonyms
- Intraval;Nesdonal;Thiothal;Pentothal;Tiopentale;THIOPENTAL;Thiomebumal;THIOPENTONE;PENTOTHAL ACID;Thiopental CRS
- CBNumber:
- CB5265910
- Molecular Formula:
- C11H18N2O2S
- Molecular Weight:
- 242.34
- MDL Number:
- MFCD00057564
- MOL File:
- 76-75-5.mol
- MSDS File:
- SDS
| Melting point | 158-160°C |
|---|---|
| Density | 1.1789 (rough estimate) |
| refractive index | 1.5440 (estimate) |
| Flash point | 11℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: complete50mg/mL |
| pka | 7.11±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 50mg/L(25 ºC) |
| CAS DataBase Reference | 76-75-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | JI8Z5M7NA3 |
| ATC code | N01AF03,N05CA19 |
| EPA Substance Registry System | 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (76-75-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-39/23/24/25-23/24/25-11 |
| Safety Statements | 36/37/39-45-36/37-16-7 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 3 |
| RTECS | CQ6300000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933595960 |
| Hazardous Substances Data | 76-75-5(Hazardous Substances Data) |
| Toxicity | cyt-hmn:leu 1500 mg/L TGANAK18(1),13,84 |
(+/-)-THIOPENTAL price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T1019 | (±)-Thiopental | 76-75-5 | 10mg | $76.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1661002 | Thiopental United States Pharmacopeia (USP) Reference Standard | 76-75-5 | 250mg | $544 | 2024-03-01 | Buy |
| Sigma-Aldrich | T1022 | (±)Thiopental solution 1.0mg/mL in methanol, analytical standard, for drug analysis | 76-75-5 | 1ml | $160 | 2024-03-01 | Buy |
| Usbiological | 290137 | Thiopental | 76-75-5 | 100mg | $370 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004399 | THIOPENTAL 95.00% | 76-75-5 | 250MG | $704.55 | 2021-12-16 | Buy |
(+/-)-THIOPENTAL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Pentothal,Abbott
Uses
A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic
Definition
ChEBI: Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It is functionally related to a 2-thiobarbituric acid. It is a conjugate acid of a thiopental(1-).
Manufacturing Process
130 g of ethyl (1-methylbutyl) malonic ester is added to a concentrated solution of sodium ethylate prepared from 34 g of sodium in absolute alcohol; with stirring, 60 g of finely divided thiourea is added, and, the mixture refluxed for 10 hours. Most or all of the solvent is evaporated and the residual mass is dissolved in cold water. The barbituric acid derivative so formed is precipitated by the addition of dilute hydrochloric acid. It may be 1 purified by solution in dilute ammonium hydroxide solution and precipitated by carbon dioxide, followed by recrystallization from 95% alcohol. The ethyl (1- methylbutyl)thiobarbituric acid so obtained is a white crystalline solid, melting at 158-159°C and readily forming salts with alkalies.
brand name
Thiopental is BAN.
Therapeutic Function
Narcotic analgesic, Anesthetic
Safety Profile
Poison by intraperitoneal, intravenous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Human mutation data reported. A short-acting intravenous anesthetic. When heated to decomposition it emits very toxic fumes of NOx and SOx
(+/-)-THIOPENTAL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23912 | 58 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9815 | 79 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9484 | 50 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9578 | 60 |
| Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd. | 029-88380327 17691182729 | 1018@dideu.com | China | 1993 | 58 |
View Lastest Price from (+/-)-THIOPENTAL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-06 | (+/-)-THIOPENTAL
76-75-5
|
US $1.00 / KG | 1KG | 99%HPLC | 100KG | Career Henan Chemical Co |
-
- (+/-)-THIOPENTAL
76-75-5
- US $1.00 / KG
- 99%HPLC
- Career Henan Chemical Co