Oclacitinib
- CAS No.
- 1208319-26-9
- Chemical Name:
- Oclacitinib
- Synonyms
- JAKi;Apoquel;Oclactinib;PF 03394197;Oclacitinib;PF03394197, >98%;Oclacitinib?, >98%;Dimethyl biphenyl-4;Oclacitinib USP/EP/BP;Oclacitinib PF-03394197
- CBNumber:
- CB52667354
- Molecular Formula:
- C15H23N5O2S
- Molecular Weight:
- 337.44
- MDL Number:
- MFCD25976611
- MOL File:
- 1208319-26-9.mol
| Melting point | 226-228°C |
|---|---|
| Density | 1.316±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20-25℃ |
| storage temp. | Refrigerator, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| pka | 11.59±0.40(Predicted) |
| form | Solid |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)/t11-,12- |
| InChIKey | HJWLJNBZVZDLAQ-HAQNSBGRSA-N |
| SMILES | [C@@H]1(CS(NC)(=O)=O)CC[C@@H](N(C)C2N=CN=C3NC=CC3=2)CC1 |
| LogP | 1.38 at 35℃ and pH7 |
| FDA UNII | 99GS5XTB51 |
Oclacitinib price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18722 | Oclacitinib ≥98% | 1208319-26-9 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 18722 | Oclacitinib ≥98% | 1208319-26-9 | 5mg | $127 | 2024-03-01 | Buy |
| Cayman Chemical | 18722 | Oclacitinib ≥98% | 1208319-26-9 | 10mg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 18722 | Oclacitinib ≥98% | 1208319-26-9 | 50mg | $505 | 2024-03-01 | Buy |
| TRC | O170000 | Oclacitinib | 1208319-26-9 | 10mg | $225 | 2021-12-16 | Buy |
Oclacitinib Chemical Properties,Uses,Production
Description
Oclacitinib is an oral JAK inhibitor that is a drug approved by the U.S. Food and Drug Administration (FDA) for use in canine atopic dermatitis (AD). The U.S. FDA and the European Medical Association have approved a number of JAK inhibitors, including baricitinib, ruxolitinib, federatinib, tofacitinib, upadacitinib, oclacitinib, but some of these drugs are still being studied. Oclacitinib mainly shows activity against JAK1-dependent cytokines and also inhibits the function of JAK2-dependent cytokines. oclacitinib modifies the production of cytokines such as IL-4 and IL-13, which are crucial for B-cell proliferation and maturation in the pathogenesis of pemphigus foliaceus. Oclacitinib could interdict the effects of IL-6, a cytokine involved in the Toll-like receptor 4-originated signaling pathway in the bladder epithelial cells, and IL-8, which could theoretically contribute to a decreased defense against the urinary pathogens[1-4].
Uses
Oclacitinib is a novel Janus kinase (JAK) inhibitor with activity against cytokines involved in allergy.
Biological Activity
janus kinase (jak) enzymes are involved in cell signaling pathways activated by cytokines dysregulated in allergy. pf-03394197 (oclacitinib) is a novel janus kinase inhibitor.
in vitro
pf-03394197 inhibited jak family members by 50% at concentrations ranging from 10 to 99 nm and did not inhibit a panel of 38 non-jak kinases. pf-03394197 was most potent at inhibiting jak1. pf-03394197 also inhibited the function of jak1-dependent cytokines involved in allergy and inflammation as well as pruritus. pf-03394197 had minimal effects on cytokines which did not activate the jak1 enzyme in cells [1].
in vivo
pf-03394197 administered orally at a dose of 0.4–0.6 mg/kg twice daily was safe and efficacious in controlling the pruritus associated with allergic dermatitis. pf-03394197 provided itch relief within 24 h that persisted through the treatment period, with over 70% of the treated dogs achieving a >50% reduction in pruritus by day 7 [2].
IC 50
10 nm for jak1
References
[1] Xin P, et al. The role of JAK/STAT signaling pathway and its inhibitors in diseases. International Immunopharmacology, 2020; 80: 549-56.
[2] Kalantari Y, et al. A literature review on Janus kinase (JAK) inhibitors for the treatment of immunobullous disorders. International Immunopharmacology, 2022; 110: 108923.[3] Erickson S, et al. New and emerging treatments for inflammatory itch. Annals of Allergy, Asthma Immunology, 2020; 126: 13-20.
[4] Xu P, et al. Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders. European Journal of Medicinal Chemistry, 2020; 129: 112155.
Oclacitinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13256 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12447 | 58 |
View Lastest Price from Oclacitinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-06 | Oclacitinib
1208319-26-9
|
US $0.00-0.00 / g | 1g | 98%min | 10000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2023-12-23 | Oclacitinib
1208319-26-9
|
US $50.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-06-16 | Oclactinib
1208319-26-9
|
US $100.00 / kg | 1kg | 99% | 500t/month | Henan Bao Enluo International TradeCo.，LTD |
-
- Oclacitinib
1208319-26-9
- US $0.00-0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Oclacitinib
1208319-26-9
- US $50.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Oclactinib
1208319-26-9
- US $100.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD