2-METHOXYESTRADIOL
- CAS No.
- 362-07-2
- Chemical Name:
- 2-METHOXYESTRADIOL
- Synonyms
- 2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
- CBNumber:
- CB5268052
- Molecular Formula:
- C19H26O3
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD00010489
- MOL File:
- 362-07-2.mol
Melting point | 188-190°C |
---|---|
Boiling point | 464.4±45.0 °C(Predicted) |
Density | 1.178±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO: 10 mg/mL |
form | crystalline |
pka | 10.29±0.60(Predicted) |
color | light yellow |
λmax | 286nm(EtOH)(lit.) |
InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
NCI Dictionary of Cancer Terms | 2-methoxyestradiol |
FDA UNII | 6I2QW73SR5 |
NCI Drug Dictionary | 2-methoxyestradiol |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS06,GHS08,GHS09 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301+H311+H331-H315-H319-H335-H350-H360-H372-H410 | |||||||||
Precautionary statements | P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
Hazard Codes | T,Xi,N | |||||||||
Risk Statements | 23/24/25-36/37/38-48-61-60-46-45-51/53 | |||||||||
Safety Statements | 22-26-36/37/39-45-53-36-61 | |||||||||
RIDADR | UN 3077 9/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | KG7537500 | |||||||||
HS Code | 2937.23.5050 | |||||||||
NFPA 704 |
|
2-METHOXYESTRADIOL price More Price(42)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 454180 | 2-Methoxyestradiol | 362-07-2 | 10mg | $113 | 2024-03-01 | Buy |
Sigma-Aldrich | 454180 | 2-Methoxyestradiol | 362-07-2 | 50mg | $417 | 2024-03-01 | Buy |
TCI Chemical | M2530 | 2-Methoxy-β-estradiol >97.0%(GC) | 362-07-2 | 25mg | $44 | 2024-03-01 | Buy |
TCI Chemical | M2530 | 2-Methoxy-β-estradiol >97.0%(GC) | 362-07-2 | 100mg | $117 | 2024-03-01 | Buy |
Cayman Chemical | 13021 | 2-Methoxyestradiol ≥95% | 362-07-2 | 5mg | $31 | 2024-03-01 | Buy |
2-METHOXYESTRADIOL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Uses
A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Uses
A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Uses
2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Uses
2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Definition
ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Biological Activity
Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
2-METHOXYESTRADIOL Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 882 | 58 | |
Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 491 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
View Lastest Price from 2-METHOXYESTRADIOL manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-07 | 2-Methoxyestradiol
362-07-2
|
US $100.00 / kg | 1kg | 99.9% | 20tons | Hong Kong Excellence Biotechnology Co., Ltd. | |
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2024-05-11 | 2-Methoxyestradiol
362-07-2
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | |
![]() |
2024-05-11 | 2-Methoxyestradiol
362-07-2
|
US $9.00-60.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD |
-
- 2-Methoxyestradiol
362-07-2
- US $100.00 / kg
- 99.9%
- Hong Kong Excellence Biotechnology Co., Ltd.
-
- 2-Methoxyestradiol
362-07-2
- US $20.00-10.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD
-
- 2-Methoxyestradiol
362-07-2
- US $9.00-60.00 / g
- 99%
- Hebei Kangcang new material Technology Co., LTD
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