ChemicalBook >> CAS DataBase List >>11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]
diazepin-6-one
11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one
![11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]
diazepin-6-one Structure](CAS/20150408/GIF/133627-24-4.gif)
- CAS No.
- 133627-24-4
- Chemical Name:
- 11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one
- Synonyms
- Nevirapine 12-Hydroxy;12-Hydroxy Nevirapine D7;12-Hydroxy Nevirapine D4;11-cyclopropyl-4-(hydroxymethyl)-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one;N11-Cyclopropyl-4-hydroxymethyl-5,11-dihydro-6H-dipyrido(3,2-b:2,3-e)(1,4)diazepin-6-one;11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2,3-e][1,4]\ndiazepin-6-one;11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one;6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-;12-Hydroxy NevirapineQ: What is 12-Hydroxy Nevirapine Q: What is the CAS Number of 12-Hydroxy Nevirapine Q: What is the storage condition of 12-Hydroxy Nevirapine
- CBNumber:
- CB52694817
- Molecular Formula:
- C15H14N4O2
- Molecular Weight:
- 282.3
- MDL Number:
- MOL File:
- 133627-24-4.mol
- MSDS File:
- SDS
Last updated:2023-05-04 17:34:33
11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one Properties
| Melting point | >184oC (dec.) |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Yellow to Light Brown |
| FDA UNII | Y6L0287CM4 |
11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C988365 | 11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2'',3''-e][1,4]diazepin-6-one | 133627-24-4 | 100mg | $1190 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 50461 | 11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2??,3??-e][1,4]diazepin-6-one | 133627-24-4 | 100mg | $2200 | 2021-12-16 | Buy |
11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one Chemical Properties,Uses,Production
Uses
11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2'',3''-e][1,4]diazepin-6-one, is a metabolite of Nevirapine (N391275), which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. It is also an antiviral.
Uses
11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, is a metabolite of Nevirapine (N391275), which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. It is also an antiviral.
Definition
ChEBI: 12-hydroxynevirapine is a dipyridodiazepine that is nevirapine in which one of the hydrogens of the methyl group has been substituted by a hydroxy group. It is a metabolite of the anti-HIV drug, nevirapine. It has a role as a drug metabolite. It is a member of cyclopropanes, a dipyridodiazepine and an aromatic primary alcohol. It is functionally related to a nevirapine.
Synthesis of 11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]
diazepin-6-one from 2-Chloro-3-pyridinamine
11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-one Preparation Products And Raw materials
Global( 12)Suppliers
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11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]
diazepin-6-one
11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2,3-e][1,4]\ndiazepin-6-one
N11-Cyclopropyl-4-hydroxymethyl-5,11-dihydro-6H-dipyrido(3,2-b:2,3-e)(1,4)diazepin-6-one
Nevirapine 12-Hydroxy
6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-
11-cyclopropyl-4-(hydroxymethyl)-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one
12-Hydroxy Nevirapine D4
12-Hydroxy Nevirapine D7
12-Hydroxy NevirapineQ: What is
12-Hydroxy Nevirapine Q: What is the CAS Number of
12-Hydroxy Nevirapine Q: What is the storage condition of
12-Hydroxy Nevirapine
133627-24-4
Anti-virals, Inhibitors, Non-nucleoside Reverse Transcriptase, Pharmaceuticals, Intermediates & Fine Chemicals