1,4-PHENYLENE DIISOTHIOCYANATE

1,4-PHENYLENE DIISOTHIOCYANATE Properties

Melting point	129-131 °C (lit.)
Boiling point	339.4±25.0 °C(Predicted)
Density	1.3675 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	−20°C
solubility	chloroform: clear
form	powder
color	white
Water Solubility	Hydrolyzes in water.
Sensitive	Moisture Sensitive
Merck	14,1308
BRN	2414340
InChIKey	OMWQUXGVXQELIX-UHFFFAOYSA-N
CAS DataBase Reference	4044-65-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	6D1R3P86GX
EPA Substance Registry System	Bitoscanate (4044-65-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H315-H319-H334-H335

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-42

Safety Statements

22-26-36/37

RIDADR

UN 2811 6.1/PG 3

WGK Germany

3

RTECS

NX9150000

F

10-21

Hazard Note

Irritant

TSCA

Yes

HazardClass

6.1

PackingGroup

II

HS Code

29291090

Toxicity

LD50 oral in mouse: 230mg/kg

NFPA 704

	1
3		1

1,4-PHENYLENE DIISOTHIOCYANATE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	258555	p-Phenylene diisothiocyanate 98%	4044-65-9	1g	$24.48	2024-03-01	Buy
Sigma-Aldrich	258555	p-Phenylene diisothiocyanate 98%	4044-65-9	5g	$143	2024-03-01	Buy
TCI Chemical	P1279	1,4-Phenylene Diisothiocyanate >98.0%(GC)	4044-65-9	5g	$112	2024-03-01	Buy
TCI Chemical	P1279	1,4-Phenylene Diisothiocyanate >98.0%(GC)	4044-65-9	25g	$384	2024-03-01	Buy
Alfa Aesar	L09756	1,4-Phenylene diisothiocyanate, 98%	4044-65-9	1g	$34.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
258555	1g	$24.48	Buy
258555	5g	$143	Buy
P1279	5g	$112	Buy
P1279	25g	$384	Buy
L09756	1g	$34.65	Buy

1,4-PHENYLENE DIISOTHIOCYANATE Chemical Properties,Uses,Production

Description

Bitoscanate is a colorless to beige, odorless,crystalline compound. Molecular weight=192.3; Freezing/Melting point=132℃. Hazard Identification (based onNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0.

Chemical Properties

off-white to yellow to beige-grey crystalline

Chemical Properties

Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.

Uses

It is used in the treatment of?hookworms.

Uses

anthelmintic

Uses

Reagent for solid-phase sequencing.

Definition

ChEBI: Bitoscanate is a member of benzenes.

General Description

Odorless colorless crystals. Melting point 132°C.

Reactivity Profile

1,4-PHENYLENE DIISOTHIOCYANATE reacts readily with amines [Noller]. These reactions may generate significant amounts of heat . Emits very toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition [EPA, 1998].

Health Hazard

1,4-PHENYLENE DIISOTHIOCYANATE is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans.

Fire Hazard

When heated to decomposition, 1,4-PHENYLENE DIISOTHIOCYANATE emits very toxic fumes of nitrogen oxides and sulfur oxides.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, nausea. When heated to decomposition it emits very toxic fumes of NOx,CN,and SOx.See also THIOCYANATES

Potential Exposure

Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. For cyanide poisoning, use amylnitrate capsules if symptoms develop. All area employeesshould be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidote kit shouldbe kept in the immediate work area and must be rapidlyavailable. Kit ingredients should be replaced every 1 2years to ensure freshness. Persons trained in the use of thiskit, oxygen use, and CPR must be quickly available.

storage

Color Code—Green: General storage may be used.Store in tightly closed containers in a cool, well-ventilatedarea. Store under inert gas; moisture sensitive.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.

Purification Methods

Purify bitoscanate by recrystallisation from AcOH, pet ether (b 40-60o), Me2CO or aqueous Me2CO. [van der Kerk et al. Recl Trav Chim Pays-Bas 74 1262 1955, Leiber & Slutkin J Org Chem 27 2214 1962, Beilstein 13 IV 174.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

1,4-PHENYLENE DIISOTHIOCYANATE synthesis

Synthesis of 1,4-PHENYLENE DIISOTHIOCYANATE from p-Phenylenediamine

1,4-PHENYLENE DIISOTHIOCYANATE Preparation Products And Raw materials

Raw materials

Lead(II) nitrate Carbon disulfide Thiophosgene p-Phenylenediamine p-Phenylenediamine, monohydrochloride

dimethyl 1,4-phenylenedicarbamodithioate 4-NITROPHENYL ISOTHIOCYANATE Sodium trifluoromethanesulfinate Carbamimidothioic acid Chloroform

Acetic anhydride 4-Nitroaniline

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Preparation Products

1,4-PHENYLENEBIS(THIOUREA)

1,4-PHENYLENE DIISOTHIOCYANATE Suppliers

Global( 154)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Shanghai Yudiao Chemistry Technology Co.,Ltd	02137285211 18964703211	info@yudiaochem.com	CHINA	238	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9725	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Shanghai Yudiao Chemistry Technology Co.,Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58
changzhou huayang technology co., ltd	58

View Lastest Price from 1,4-PHENYLENE DIISOTHIOCYANATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Bitoscanate 4044-65-9	US $39.00-29.00 / mg		98.32%	10g	TargetMol Chemicals Inc.
2024-11-19	Bitoscanate 4044-65-9	US $39.00-29.00 / mg		98.32%	10g	TargetMol Chemicals Inc.
2019-09-02	1,4-PHENYLENE DIISOTHIOCYANATE 4044-65-9	US $1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

Bitoscanate
4044-65-9
US $39.00-29.00 / mg
98.32%
TargetMol Chemicals Inc.

Bitoscanate
4044-65-9
US $39.00-29.00 / mg
98.32%
TargetMol Chemicals Inc.

1,4-PHENYLENE DIISOTHIOCYANATE
4044-65-9
US $1.00 / KG
98%
Career Henan Chemical Co

1,4-PHENYLENE DIISOTHIOCYANATE Spectrum

1,4-PHENYLENE DIISOTHIOCYANATE(4044-65-9)MS 1,4-PHENYLENE DIISOTHIOCYANATE(4044-65-9)¹HNMR 1,4-PHENYLENE DIISOTHIOCYANATE(4044-65-9)¹³CNMR 1,4-PHENYLENE DIISOTHIOCYANATE(4044-65-9)IR1 1,4-PHENYLENE DIISOTHIOCYANATE(4044-65-9)IR2 1,4-PHENYLENE DIISOTHIOCYANATE(4044-65-9)Raman

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1,4-diisothiocyanato-benzen 1,4-diisothiocyanatobenzene[qr] 1,4-phenylenedi-isothiocyanicaci Phenylene-1,4-diisothiocyanate, 1,4-Diisothiocyanatobenzene PDITC p-Phenylene diisothiocyanate 98% p-Phenylene diisothiocyanate(PDITC) 1,4-Phenylene diisothiocyanate for synthesis 16842(uspddn)[qr] ai3-28258[qr] Benzene, 1,4-diisothiocyanato- benzene,1,4-diisothiocyanato-[qr] Biscomate Bitoscanat bitoscanato[qr] bitoscanatum(latin)[qr] Isothiocyanic acid, 1,4-phenylenedi- Isothiocyanic acid, p-phenylene ester isothiocyanicacid,p-phenyleneester[qr] isothiocyanicacidp-phenyleneester Jonit jonit[qr] Phenylene 1,4-diisothiocyanate Phenylene thiocyanate phenylene-1,4-diisothiocyanate phenylene-1,4-diisothiocyanate[qr] phenylenethiocyanate p-Phenylene bis(isothiocyanate) WM 842 wm842[qr] P-PHENYLENE DIISOTHIOCYANATE PHENYLENEDIISOTHIOCYANATE(1,4-) BENZENE 1,4-DIISOTHIOCYANATE BITOSCANATE DITC 1,4-PHENYLENE DIISOTHIOCYANATE 1,4-DIISOTHIOCYANATOBENZENE 1,4-Phenylenediisocyanate, GC 97% DITC, 1,4-Diisothiocyanatobenzene Bitoscanate: (1,4-Phenylenediisothiocyanic acid) 1,4-Diisothiocyanatobenzene, Bitoscanate, PDITC 16842 Benzene 1,4-Diisothiocyanate Bitoscanate 1,4-Diisothiocyanatobenzene p-Phenylene diisothiocyanate ,98.5% 1,4-Phenylendiisothiocyanate p-Phenylene diisothiocyanate, 99% 25GR p-Phenylene diisothiocyanate, 99% 5GR p-Phenylene diisothiocyanate,99% 1,4-Phenylene diisothiocyate, 98% 4-Diisothiocyanatobenzene JACS-4044-65-9 1,4-PhenyleneDiisothiocyanate> 1,4-Diisothiocyanatobenzol p-Phenylene diisothiocyanate|||Biscomate|||PDITC|||1,4-Diisothiocyanatobenzene 4044-65-9 C6H4NCS2 C8H4N2S2 UV-VIS