2-Fluoro-5-formylbenzonitrile
- CAS No.
- 218301-22-5
- Chemical Name:
- 2-Fluoro-5-formylbenzonitrile
- Synonyms
- 3-CYANO-4-FLUOROBENZALDEHYDE;2-Fluor-5-formylbenzonitrile;FFBN;uoro-5-formyL;CYANOFLUOROBENZALDEHYDE-3-4;4-Fluoro-3-cyanobenzaldehyde;2-FLUORO-5-FORMYLBENZONITRILE;3-cyano-4-flluorobenzaldehyde;2-Fluoro-S-formylbenzonitrile;3-Cyano-4-fluorobenzaldehyde97%
- CBNumber:
- CB5293829
- Molecular Formula:
- C8H4FNO
- Molecular Weight:
- 149.12
- MDL Number:
- MFCD01863558
- MOL File:
- 218301-22-5.mol
- MSDS File:
- SDS
| Melting point | 80-84 °C (lit.) |
|---|---|
| Boiling point | 215.6±20.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Solid |
| color | White |
| InChI | InChI=1S/C8H4FNO/c9-8-2-1-6(5-11)3-7(8)4-10/h1-3,5H |
| InChIKey | MOFRJTLODZILCR-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC(C=O)=CC=C1F |
| CAS DataBase Reference | 218301-22-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335-H302+H312+H332 |
| Precautionary statements | P264-P270-P271-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P261-P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Hazard Note | Harmful |
| HazardClass | IRRITANT |
| HS Code | 29269090 |
2-Fluoro-5-formylbenzonitrile price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 494089 | 2-Fluoro-5-formylbenzonitrile 97% | 218301-22-5 | 5g | $351 | 2023-06-20 | Buy |
| TCI Chemical | C2692 | 3-Cyano-4-fluorobenzaldehyde >98.0%(GC) | 218301-22-5 | 1g | $32 | 2024-03-01 | Buy |
| TCI Chemical | C2692 | 3-Cyano-4-fluorobenzaldehyde >98.0%(GC) | 218301-22-5 | 5g | $94 | 2024-03-01 | Buy |
| TRC | C987515 | 3-Cyano-4-fluorobenzaldehyde | 218301-22-5 | 10g | $950 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4637-3-14 | 3-Cyano-4-fluorobenzaldehyde 98% | 218301-22-5 | 25g | $75 | 2021-12-16 | Buy |
2-Fluoro-5-formylbenzonitrile Chemical Properties,Uses,Production
Description
2-Fluoro-5-formylbenzonitrile is a pharmaceutical intermediate compound used in the preparation of Olaparib, a PARP inhibitor for the treatment of a variety of cancers including advanced ovarian, fallopian tube, or primary peritoneal cancers with a certain hereditary (germline) or acquired (somatic) abnormality of the BRCA gene.
Chemical Properties
White Solid
Uses
2-Fluoro-5-formylbenzonitrile may be used in the synthesis of 3-cyano-4-fluorobenzyl bromide. It could be used to synthesis 2-fluoro-5-(4-ethoxybenzyl)benzonitrile. 2-Fluoro-5-formylbenzonitrile (10g, 1eq) was dissolved in 100mL 1,4-dioxane, p-toluenesulfonyl hydrazide (13.7g, 1eq) was added, stirred at room temperature for 3 hours, and then added Potassium carbonate (13.9 g, 1.5 eq), 4-ethoxyphenylboronic acid (12.2 g, 1 eq), warmed to 100 C. and stirred for 12 hours. After TLC monitoring the reaction of the raw materials, filter, spin dry the filtrate, add petroleum ether and stir for half an hour, filter, and spin dry the filtrate to obtain 15 g of 2-fluoro-5-(4-ethoxybenzyl)benzonitrile (the yield is 88%).
Uses
2-Fluoro-5-ForMyl-benzonitrile is used in the preparation of heterocyclic compounds as PARP inhibitors for medical use.
General Description
2-Fluoro-5-formylbenzonitrile is a benzonitrile derivative.
2-Fluoro-5-formylbenzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmOrgSyn Laboratories Co., Ltd. | +86-021-38228826 +86-13916602830 | sales@pharmorgsyn.cn | China | 140 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| CHANGZHOU HARVECHEM LTD | +86-0519-88784888 +8613906120163 | inquiry@harvechem.com | China | 271 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Suzhou Nordica Biopharma CO.,LTD | +86-18136148818 +86-18567353071 | 3537297702@qq.com | China | 299 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20262 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
View Lastest Price from 2-Fluoro-5-formylbenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-14 | 2-fluoro-5-formylbenzonitrile
218301-22-5
|
US $0.00-0.00 / kg | 0.1kg | 0.99 | 1 tons | Suzhou Nordica Biopharma CO.,LTD | |
 |
2025-01-03 | 3-Cyano-4-fluorobenzaldehyde
218301-22-5
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |
 |
2024-11-26 | 2-Fluoro-5-formylbenzonitrile
218301-22-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- 2-fluoro-5-formylbenzonitrile
218301-22-5
- US $0.00-0.00 / kg
- 0.99
- Suzhou Nordica Biopharma CO.,LTD
-
- 3-Cyano-4-fluorobenzaldehyde
218301-22-5
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 2-Fluoro-5-formylbenzonitrile
218301-22-5
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd