3-FLUORO-5-FORMYLBENZONITRILE
- CAS No.
- 1003708-42-6
- Chemical Name:
- 3-FLUORO-5-FORMYLBENZONITRILE
- Synonyms
- 3-FLUORO-5-FORMYLBENZONITRILE;Benzonitrile, 3-fluoro-5-formyl-;4-Chloro-4-(trifluoromethyl)acetophenone
- CBNumber:
- CB7534339
- Molecular Formula:
- C8H4FNO
- Molecular Weight:
- 149.12
- MDL Number:
- MFCD04974123
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319-H335-H302+H312+H332-H315 |
Precautionary statements | P260-P280-P301+P310 |
HS Code | 2926907090 |
3-FLUORO-5-FORMYLBENZONITRILE price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | F532040 | 3-Fluoro-5-formylbenzonitrile | 1003708-42-6 | 1g | $145 | 2021-12-16 | Buy |
AK Scientific | X8502 | 3-Fluoro-5-formylbenzonitrile | 1003708-42-6 | 250mg | $32 | 2021-12-16 | Buy |
Matrix Scientific | 067013 | 3-Fluoro-5-formylbenzonitrile >95% | 1003708-42-6 | 500mg | $65 | 2021-12-16 | Buy |
Matrix Scientific | 067013 | 3-Fluoro-5-formylbenzonitrile >95% | 1003708-42-6 | 5g | $250 | 2021-12-16 | Buy |
Apolloscientific | PC200339 | 3-Fluoro-5-formylbenzonitrile 98% | 1003708-42-6 | 5g | $254 | 2021-12-16 | Buy |
3-FLUORO-5-FORMYLBENZONITRILE Chemical Properties,Uses,Production
Uses
3-Fluoro-5-formylbenzonitrile is benzaldehyde based building block used as a reactant in catalyst-free synthesis of N-β-hydroxyethyl pyrroles and indoles via a domino [3+2] cycloaddition and ring-opening aromatization process.
Application
3-FLUORO-5-FORMYLBENZONITRILE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
3 -fluoro-5 -formylbenzonitrile : A solution of 3 -bromo-5 -fluorobenzonitrile(5.00 g, 25.0 mmol) in dry THF (25 mL) was cooled to 0 °C and 2M iPrMgCl (15.0 mL, 30.0 mmol) in THF was added dropwise over 5 minutes. The mixture was stirred at 0 °C for 15 minutes then at ambient temperature for 1 hour. The mixture was cooled to 0 °C and dry DMF (5.81 mL, 75.0 mmol) was added. The mixture was stirred for 17 hours during which time the temperature reached ambient temperature after 2 hours. The mixture was added to ice water (150 mL) and Et20 (100 mL). The biphasic mixture was stirred and treated with 6M HC1 to aqueous pH=3. The organic layer was removed and the aqueous layer extracted with Et20 (2X). The combined Et20 fractions were washed with saturated NaCl and dried over MgS04/activated carbon. The dried solution was filtered through a S1O2 plug eluting with Et20. The filtrate was concentrated to give the title compound as a yellow solid that was dried in vacuum (3.68 g, 99percent). 1H NMR (CDC13) δ 10.0 (s, 1H), 8.00 (s, 1H), 7.81-7.86 (m, 1H), 7.62-7.67 (m, 1H).
3-FLUORO-5-FORMYLBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1377 | 60 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 993 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5791 | 58 |
View Lastest Price from 3-FLUORO-5-FORMYLBENZONITRILE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2020-01-03 | 3-FLUORO-5-FORMYLBENZONITRILE
1003708-42-6
|
US $1.00 / KG | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
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- 3-FLUORO-5-FORMYLBENZONITRILE
1003708-42-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co