3-Bromo-5-fluorobenzonitrile
- CAS No.
- 179898-34-1
- Chemical Name:
- 3-Bromo-5-fluorobenzonitrile
- Synonyms
- CAS:179898-34-1;3-BROMO-5-FLUOROBENZONITRILE;3-Cyano-5-fluorobromobenzene;3-BroMo-5-fluoronitrobenzene;3-Bromo-5-fluorobenzonitrole;Benzonitrile, 3-bromo-5-fluoro-;3-Bromo-5-fluorobenzonitrile98%;3-Bromo-5-fluorobenzonitrile 98%;-Bromo-5-fluorobenzonitrile 98%
- CBNumber:
- CB3184567
- Molecular Formula:
- C7H3BrFN
- Molecular Weight:
- 200.01
- MDL Number:
- MFCD04038227
- MOL File:
- 179898-34-1.mol
| Melting point | 43 °C |
|---|---|
| Boiling point | 218.7±20.0 °C(Predicted) |
| Density | 1.69±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to lump |
| color | White to Almost white |
| CAS DataBase Reference | 179898-34-1(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H315-H319-H331-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-36-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 3439 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
3-Bromo-5-fluorobenzonitrile price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS003867 | 3-Bromo-5-fluorobenzonitrile AldrichCPR | 179898-34-1 | 250mg | $61.6 | 2023-06-20 | Buy |
| TCI Chemical | B4600 | 3-Bromo-5-fluorobenzonitrile >98.0%(GC) | 179898-34-1 | 1g | $16 | 2024-03-01 | Buy |
| TCI Chemical | B4600 | 3-Bromo-5-fluorobenzonitrile >98.0%(GC) | 179898-34-1 | 5g | $63 | 2024-03-01 | Buy |
| Alfa Aesar | H26066 | 3-Bromo-5-fluorobenzonitrile, 98% | 179898-34-1 | 1g | $20.65 | 2024-03-01 | Buy |
| Alfa Aesar | H26066 | 3-Bromo-5-fluorobenzonitrile, 98% | 179898-34-1 | 10g | $130.65 | 2024-03-01 | Buy |
3-Bromo-5-fluorobenzonitrile Chemical Properties,Uses,Production
Chemical Properties
off-white crystalline
Uses
3-Bromo-5-fluorobenzonitrile is a compound of benzonitrile containing bromine and fluorine atoms, which is mainly used as an intermediate component in organic synthesis.
Synthesis
3-Bromo-5-fluorobenzonitrile is synthesised using 1,3-dibromo-5-fluorobenzene as a raw material by chemical reaction. The specific synthesis steps are as follows:
A 250-mL round-bottom flask equipped with a magnetic stir bar was charged with 1,3-dibromo-5-fluorobenzene (7.70 g, 30.3 mmol), DMF (45 mL), pyridine (4.9 mL), and copper (I) cyanide (2.72 g, 30.3 mmol) under nitrogen.
A reflux condenser was attached to the flask.
The green, cloudy mixture was stirred at reflux for 3 h.
Once lower Rf impurities were observed, the reaction was allowed to cool to room temperature.
The reaction was quenched with 30 mL of ether, and a precipitate formed in the dark solution.
The precipitate was gravity-filtered though Celite.
The filtrate was rinsed three times with ether (100 mL/50 g bromide).
The isolated solution was added to a separatory funnel.
The organic layer was washed with a 2:1 mixture of water and concentrated ammonium hydroxide (30 mL), followed by saturated ammonium chloride solution (2*30 mL) and saturated sodium bicarbonate (30 mL).
The aqueous layers were extracted with ether (3*40 mL).
The organic layers were combined and dried over anhydrous sodium sulfate.
The product was purified by flash column chomatography to yield 3-bromo-5-fluorobenzonitrile (2.10 g, 35percent).
1H NMR (400 MHz, CDCl3) δ 7.62 (s, 1H), 7.54-7.50 (m, 1H), 7.35-7.32 (m, 1H).
3-Bromo-5-fluorobenzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19825 | 58 |
View Lastest Price from 3-Bromo-5-fluorobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-23 | 3-Bromo-5-fluorobenzonitrile
179898-34-1
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-03-21 | 3-Bromo-5-fluorobenzonitrile
179898-34-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2019-07-06 | 3-Bromo-5-fluorobenzonitrile
179898-34-1
|
US $8.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 3-Bromo-5-fluorobenzonitrile
179898-34-1
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Bromo-5-fluorobenzonitrile
179898-34-1
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 3-Bromo-5-fluorobenzonitrile
179898-34-1
- US $8.00 / kg
- 98%
- Career Henan Chemical Co
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