Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Kasugamycin hydrochloride

Kasugamycin hydrochloride

Kasugamycin hydrochloride Structure
Kasugamycin hydrochloride structure
CAS No.
19408-46-9
Chemical Name:
Kasugamycin hydrochloride
Synonyms
kasumin;Kasugamycin hy;KasugaMycin HCl;kasugamycin (jmaff);KASUGAMYCIN HYDROCHL;KASUGAMYCIN HCL HYDRATE;Ksugamycinhydrochloride;KASUGAMYCIN HYDROCHLORIDE;Kasugamycin HCl, Monohydrate;kasugamycin,monohydrochloride
CBNumber:
CB5297221
Molecular Formula:
C14H25N3O9.ClH
Molecular Weight:
415.82
MDL Number:
MFCD00058459
MOL File:
19408-46-9.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:52
Request For Quotation

Kasugamycin hydrochloride Properties

Melting point 202-204 °C (decomp)
vapor pressure <1.3x l0-8 Pa (25 °C)
storage temp. Sealed in dry,2-8°C
solubility H2O: soluble
pka 3.23 (carboxyl), 7.73 and 11.0 (bases)
Water Solubility 125 g l-1 (25 °C)
form Solid
color white to off-white
Stability Hygroscopic
CAS DataBase Reference 19408-46-9(CAS DataBase Reference)
FDA UNII SXA18D440T
EPA Substance Registry System Kasugamycin monohydrochloride (19408-46-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements  22-24/25-26
WGK Germany  2
RTECS  NM7521800

Kasugamycin hydrochloride price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich K4013 Kasugamycin hydrochloride from Streptomyces kasugaensis ≥90% (HPLC) 19408-46-9 10g $402 2024-03-01 Buy
Sigma-Aldrich 32354 Kasugamycin hydrochloride VETRANAL 19408-46-9 100mg $69.5 2024-03-01 Buy
Alfa Aesar J67325 Kasugamycin, 50 mg/ml in distilled water, sterile-filtered 19408-46-9 25ml $294 2023-06-20 Buy
Alfa Aesar J67325 Kasugamycin, 50 mg/ml in distilled water, sterile-filtered 19408-46-9 50ml $340 2021-12-16 Buy
Cayman Chemical 15322 Kasugamycin (hydrochloride) ≥70% 19408-46-9 1g $48 2023-06-20 Buy
Product number Packaging Price Buy
K4013 10g $402 Buy
32354 100mg $69.5 Buy
J67325 25ml $294 Buy
J67325 50ml $340 Buy
15322 1g $48 Buy

Kasugamycin hydrochloride Chemical Properties,Uses,Production

Description

Kasugamycin is an aminoglycosidic antibiotic isolated from S. kasugaensis. It blocks the initiation of translation, preventing initiation complex formation on 30S ribosomes in bacteria.

Uses

kasugamycin, derived from Streptomyces kasuguensis, is also used to control rice blast.It acts by inhibiting protein synthesis by interfering with the binding of aminoacyl-tRNA to the mRNA-30s ribosomal subunit complex (Yamaguchi, 1998).

Uses

antifungal

Uses

Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.

in vitro

kasugamycin could inhibit protein synthesis by interacting with the 30s ribosomal subunit. the mechanism of inhibition of protein synthesis appeared to be different from that of other aminoglycosides, such as kanamycin, streptomycin, neomycin, gentamicin. the initiation complex formation on 30s ribosomes could be inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, though the binding of fmet-trna to 70s ribosomes was inhibited by both streptomycin and by kasugamycin. [1].

in vivo

five groups, each consisting of five guinea pigs, were infected with shibaura strain; two groups were treated by injection with kasugamycin. all animals treated with 1 mcg/g were killed showing an average survival period of 7.4 days, which was close to the average survival period of 6.2 days in the control group; while all animals treated with 5 mcg/g survived. the other two groups were treated with kasugamycin from the icteric stage to the 10th day after infection. two animals of the 5 mcg/g group survived, showing no leptospira in the kidney; the other three died in an average of 7.7 days. three animals of the 10 mcg/g group survived; while the other two animals died in 6.5 days on an average . the total amounts of kasugamycin administered to the infected guinea pigs from the febrile stage were 10.8 mg (the 1 mcg/g group) and 54.0 mg (the 5 mcg/g group) [2].

Metabolic pathway

kasugamycin hydrochloride hydrate is a relatively stable antibiotic. There is limited published information on its metabolism and environmental fate but it is extensively degraded in plants and soil as indicated in Scheme 1.

Degradation

kasugamycin hydrochloride hydrate is very stable at room temperature. It is stable in weak acids but unstable in strong acids and under basic conditions. Its DT50 values at 50 °C are 47 and 14 days at pH 5 and 9, respectively (PM).

References

[1] okuyama, a. ,machiyama, n.,kinoshita, t., et al. inhibition by kasugamycin of initiation complex formation on 30s ribosomes. biochemical and biophysical research communications 43(1), 196-199 (1971).
[2] kitaoka m, mori m, arimitsu y. in vitro and in vivo effects of kasugamycin on leptospira icterohaemorrhagiae. jpn j med sci biol. 1975 oct-dec;28(5-6):285-90.

Kasugamycin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Kasugamycin hydrochloride Suppliers

Global( 159)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12837 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17365 58
Supplier Advantage
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Bao Enluo International TradeCo.，LTD 		58
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Shenzhen Excellent Biotech Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58

View Lastest Price from Kasugamycin hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Kasugamycin hydrochloride pictures 2024-12-13 Kasugamycin hydrochloride
19408-46-9
 US $0.00-0.00 / Kg/Drum 1KG 70%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Kasugamycin hydrochloride pictures 2024-12-05 Kasugamycin hydrochloride
19408-46-9
 US $10.00-8.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
Kasugamycin hydrochloride pictures 2024-11-26 Kasugamycin hydrochloride
19408-46-9
 US $3.20 / Kg/Drum 1KG 99% 20tons per month qingdao trust agri chemical co.,ltd

19408-46-9(Kasugamycin hydrochloride)Related Search:

BISMERTHIAZOL Ethylicin Propineb KASUGAMYCIN HYDROCHLORIDE KASUGAMYCIN
D-chiro-inositol Kasugamycin hydrochloride

1of2

kasugamycin,monohydrochloride kasumin 3-o-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-d-arabino-hexopyranosyl]-d-chiro-inositol kasugamycin (jmaff) kasugamycin hydrochloride from streptomyces kasugaensis (5-amino-2-methyl-6-(2,3,4,5,6-pentahydroxycyclohexyloxy)tetrahydropryan-3-yl)amino-alpha-iminoacetic acid 3-o-(2-amino-4-((carboxyiminomethyl)amino)-2,3,4,6-tetradeoxy-alpha-d-arabino-hexopyranosyl)-d-chiro-inosito monohydrochloride KASUGAMYCIN HYDROCHLORIDE KASUGAMYCIN HCL HYDRATE (5-amino-2-methyl-6-(2,3,4,5,6-pentahydroxycyclohexyloxy)tetrahydropryan-3-yl)amino-alpha-iminoaceti 3-o-(2-amino-4-((carboxyiminomethyl)amino)-2,3,4,6-tetradeoxy-alpha-d-arabino-hexopyranosyl)-d-chiro-inositomonohydrochloride KASUGAMYCIN HYDROCHLORIDE HYDRATE KASUGAMYCIN HYDROCHL KasugaMycin HCl Kasugamycin hy 3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol hydrochloride 2-(((2R,3S,5S,6R)-5-Amino-2-methyl-6-(((1R,2R,3S,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)amino)-2-iminoacetic acid hydrochloride Kasugamycinhydrochloride Solution in Methanol/Water, 100μg/mL Kasugamycin hydrochloride Solution in Methanol/Water, 1000μg/mL Kasugamycin hydrochloride USP/EP/BP Kasugamycin HCl, Monohydrate Kasugamycin hydrochloride, ≥90% (HPLC) D-chiro-Inositol,3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-a-D-arabino-hexopyranosyl]-, monohydrochloride D-chiro-Inositol, 3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-α-D-arabino-hexopyranosyl]-, hydrochloride (1:1) Ksugamycinhydrochloride Kasugamycin hydrochloride hydrate in Methanol Kasugamycin Hydrochloride in Water Kasugamycin hydrochloride hydrate in Acetonitrile 19408-46-9 C14H25N3O9 C14H26ClN3O9 C14H25N3O9HClH2O C14H28ClN3O10 FUNGICIDE Inhibitors