Vasicine
- CAS No.
- 6159-55-3
- Chemical Name:
- Vasicine
- Synonyms
- PEGANINE;1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL;C10733;vasicin;VASICINE;ST012797;TOS-BB-0711;NCI60_030781;(-)-Vasicine;AKOS NCG1-0080
- CBNumber:
- CB5300633
- Molecular Formula:
- C11H12N2O
- Molecular Weight:
- 188.23
- MDL Number:
- MFCD01544498
- MOL File:
- 6159-55-3.mol
- MSDS File:
- SDS
| Melting point | 211.5°C |
|---|---|
| Boiling point | 323.23°C (rough estimate) |
| Density | 1.1124 (rough estimate) |
| refractive index | 1.5850 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO : 83.33 mg/mL (442.70 mM; Need ultrasonic) |
| form | Powder |
| pka | 13.08±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | 6C2ZBI733P |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | 1544 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
Vasicine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11760 | Vasicine ≥95% | 6159-55-3 | 1mg | $45 | 2021-12-16 | Buy |
| Cayman Chemical | 11760 | Vasicine ≥95% | 6159-55-3 | 5mg | $191 | 2021-12-16 | Buy |
| Cayman Chemical | 11760 | Vasicine ≥95% | 6159-55-3 | 10mg | $324 | 2021-12-16 | Buy |
| TRC | T304240 | 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol | 6159-55-3 | 50mg | $155 | 2021-12-16 | Buy |
| AK Scientific | V1716 | Vasicine | 6159-55-3 | 1mg | $160 | 2021-12-16 | Buy |
Vasicine Chemical Properties,Uses,Production
Description
This quinazoline alkaloid was first isolated from the leaves of Adhatoda vasica
Nees by Hooper and subsequently discovered in Peganum harmala under the
name Peganine. The base is optically inactive although Spath and Kesztler have
reported the isolation of the (-)-form from the fresh leaves of A. vasica and
Rosenfeld and Kolesnikow have obtained the same form from the flowers and
stems of Peganum harmala. The salts are readily obtained crystalline, e.g. the
hydrochloride dihydrate, m.p. 208°C (dry); hydriodide dihydrate, m.p. 195°C
(dry); picrate, m.p. 199°C (dec.) and the methiodide, m.p. 187°C.
With AcOH, the alkaloid gives an anomalous acetyl derivative, m.p. 165°C,
subsequently shown to be N-acetylpedadiene. Oxidation with KMn04 gives
4-quinazolone and 4-keto-3 :4-dihydroxyquinazolyl-3-acetic acid, the latter
characterized as the methyl ester, m.p. 152°C.
The crude drug from A. vasica is used in India as a remedy for asthma while
the pure alkaloid acts as a bronchodilator.
Chemical Properties
White needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from camels.
Biological Activity
Vasicine, isolated from A. vasica, is an alkaloid. It is a natural cholinesterase (cholinesterase) inhibitor, has anticholinesterase activity in preclinical models, and can be used for the development of therapeutic drugs for Alzheimer's disease.
target
Antifection | AChR
References
Hooper., Pharm. J., 18,841 (1888)
Sen, Ghose.,J. Ind. Chem. Soc., 1,315 (1924)
Ghose., ibid, 4, 1 (1927)
Spath, Nakawitz., Ber., 67,45 (1934)
Spath, Kuffner., ibid, 67, 1494 (1934)
Narang, Ray., Chem. & Ind., 53,698 (1934)
Hanford, Liang, Adams., J. Amer. Chem. Soc., 56, 2780 (1934)
Ghoseetal., ibid, 57,921,951 (1935)
Rosenfeld, Kolesnikov., Ber., 69, 2022 (1936)
Pharmacology:
Chopra., Ind. Med. Gaz., 60, 354 (1925)
Tutaev, Makarova., Trans. Ukraine Inst. Exp. Pharm., 1,32 (1938)
Vasicine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3270 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15395 | 58 |
