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2-CHLORO-4-METHOXYPYRIMIDINE

2-CHLORO-4-METHOXYPYRIMIDINE structure

CAS No.: 22536-63-6

Chemical Name:: 2-CHLORO-4-METHOXYPYRIMIDINE

Synonyms: 2-chloro-4-methoxy pyrimdine;2-Chloro-6-methoxypyrimidine;2-CHLORO-4-METHOXYPYRIMIDINE;2-Chloro-4-methoxy-1,2-diazine;Pyrimidine, 2-chloro-4-methoxy-;2-Chloro-4-methoxypyrimidine 98%;Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI);2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH

CBNumber:: CB5304318

Molecular Formula:: C5H5ClN2O

Molecular Weight:: 144.56

MDL Number:: MFCD00194055

MOL File:: 22536-63-6.mol

MSDS File:: SDS

Last updated:2024-11-12 17:13:25

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2-CHLORO-4-METHOXYPYRIMIDINE Properties

Melting point	54-57 °C (lit.)
Boiling point	96-97 °C(Press: 18 Torr)
Density	1.292±0.06 g/cm3(Predicted)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	0.07±0.20(Predicted)
form	Crystalline Powder
color	White to yellow
InChIKey	BDXYNMVQMBCTDB-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29335990

2-CHLORO-4-METHOXYPYRIMIDINE price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	536458	2-Chloro-4-methoxypyrimidine 98%	22536-63-6	1g	$30	2023-06-20	Buy
Sigma-Aldrich	536458	2-Chloro-4-methoxypyrimidine 98%	22536-63-6	5g	$59.9	2023-06-20	Buy
TRC	C367688	2-Chloro-4-methoxypyrimidine	22536-63-6	500mg	$60	2021-12-16	Buy
Apolloscientific	OR46001	2-Chloro-4-methoxypyrimidine	22536-63-6	100g	$849	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0019214	2-CHLORO-4-METHOXYPYRIMIDINE 95.00%	22536-63-6	2.5G	$852.21	2021-12-16	Buy

Product number	Packaging	Price	Buy
536458	1g	$30	Buy
536458	5g	$59.9	Buy
C367688	500mg	$60	Buy
OR46001	100g	$849	Buy
HCH0019214	2.5G	$852.21	Buy

2-CHLORO-4-METHOXYPYRIMIDINE Chemical Properties,Uses,Production

Uses

2-Chloro-4-methoxypyrimidine is a pharmaceutical intermediate compound used in the preparation of Rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of Human Immunodeficiency Virus (HIV) infections, which prevents the replication of the virus.

Synthesis

2-Chloro-4-methoxypyrimidine is prepared by the reaction of 2,4-Dichloropyrimidine and Sodium Methoxide. The specific synthesis steps are as follows:
To a solution of 2,4-dichloropyrimidine (41.8 g, 280 mmol) in methanol (900 mL)was added a solution of CH3ONa (15.2 g, 280 mmol) in 100 mL methanol at 0 °C. The mixturewas stirred at rt for overnight. The mixture was concentrated under reduce pressure to give awhite solid, which was diluted with water (400mL) and extracted with ethyl acetate (500 mL x3). The combined organic layer was washed with brine, dried, concentrated to give 2-chloro-4-methoxypyrimidine (40 g, yield: 98percent) as white solid. ESI-MS (M+H): 145.0. ‘H NMR (400 MHz, CDC13) (5: 8.30 (d, J= 5.6 Hz ,1H), 6.68 (s, J= 5.6 Hz ,1H), 4.02 (s, 3H).
2-CHLORO-4-METHOXYPYRIMIDINE synthesis

2-CHLORO-4-METHOXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

Pyrimidine, 4-chloro-2-methoxy- (9CI) 2,4-Dichloropyrimidine Sodium Methoxide

Preparation Products

DITHIOURACIL 4-methoxy-2-Pyrimidineacetic acid methyl ester 2-Chloro-4-methoxypyrimidine-5-carbaldehyde

2-CHLORO-4-METHOXYPYRIMIDINE Suppliers

Global( 216)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	452	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17254	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58

Supplier	Advantage
Hebei Zhuanglai Chemical Trading Co Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from 2-CHLORO-4-METHOXYPYRIMIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	2-Chloro-4-MethoxypyriMidine 22536-63-6	US $10.00 / kg	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd
2024-04-17	2-Chloro-4-MethoxypyriMidine 22536-63-6	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2023-03-20	2-CHLORO-4-METHOXYPYRIMIDINE 22536-63-6	US $0.00-0.00 / kg	1kg	98%	100kg	LY Global chemicals co.,ltd .

2-Chloro-4-MethoxypyriMidine
22536-63-6
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

2-Chloro-4-MethoxypyriMidine
22536-63-6
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-CHLORO-4-METHOXYPYRIMIDINE
22536-63-6
US $0.00-0.00 / kg
98%
LY Global chemicals co.,ltd .

22536-63-6(2-CHLORO-4-METHOXYPYRIMIDINE)Related Search:

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2-CHLORO-4-METHOXYPYRIMIDINE Pyrimidine, 2-chloro-4-methoxy- (6CI,8CI,9CI) 2-Chloro-6-methoxypyrimidine 2-Chloro-4-methoxy-1,2-diazine 2-Chloro-4-methoxypyrimidine 98% Pyrimidine, 2-chloro-4-methoxy- 2-CHLORO-4-METHOXYPYRIMIDINE ISO 9001：2015 REACH 2-chloro-4-methoxy pyrimdine 22536-63-6 Building Blocks Pyrimidines Halogenated Heterocycles Heterocyclic Building Blocks Heterocycle-Pyrimidine series Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks pharmacetical Halides Pyrazines, Pyrimidines & Pyridazines Pyrimidines PYRIMIDINE