WWL229
- CAS No.
- 1338575-28-2
- Chemical Name:
- WWL229
- Synonyms
- WWL229;Reaxys ID: 25732135;WWL229, 10 mM in DMSO;XVBRVSAGMWRVCK-UHFFFAOYSA-N;WWL 229,WWL-229,Inhibitor,inhibit,WWL229;WWL229 4-Nitrophenyl 2-(3-methoxypropyl) piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 2-(3-methoxypropyl)-, 4-nitrophenyl ester
- CBNumber:
- CB53067597
- Molecular Formula:
- C16H22N2O5
- Molecular Weight:
- 322.36
- MDL Number:
- MFCD28160858
- MOL File:
- 1338575-28-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
WWL229 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1180 | WWL229 ≥98% (HPLC) | 1338575-28-2 | 5mg | $47.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1180 | WWL229 ≥98% (HPLC) | 1338575-28-2 | 25mg | $462 | 2024-03-01 | Buy |
| Cayman Chemical | 16182 | WWL229 ≥98% | 1338575-28-2 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16182 | WWL229 ≥98% | 1338575-28-2 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16182 | WWL229 ≥98% | 1338575-28-2 | 10mg | $193 | 2024-03-01 | Buy |
WWL229 Chemical Properties,Uses,Production
Uses
WWL229 is a selective inhibitor of Ces3 (carboxylesterase-3) which mediates triglyceride hydrolysis in white adipose tissue. Potential anti-diabetic agent.
Biological Activity
WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids th at can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.
WWL229 Preparation Products And Raw materials
Raw materials
Preparation Products
WWL229 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30235 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4569 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
