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WS3

WS3 structure

CAS No.: 1421227-52-2

Chemical Name:: WS3

Synonyms: CS-1800;WS3, >=98%;WS-3; WS 3;WS3 USP/EP/BP;WS3, 1421227-52-2;WS3, 10 mM in DMSO;insulin,pancreatic,pigment,WS3,proliferation,epithelial,β cell,WS 3,WS-3,Inhibitor,R7T1,diabete,RPE,inhibit,retinal;N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE;N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)amino]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide;N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide

CBNumber:: CB12723012

Molecular Formula:: C28H30F3N7O3

Molecular Weight:: 569.58

MDL Number:: MFCD26142950

MOL File:: 1421227-52-2.mol

Last updated:2024-11-19 20:33:22

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WS3 Properties

Boiling point	632.9±55.0 °C(Predicted)
Density	1.423±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: soluble10mg/mL, clear
pka	11.82±0.20(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H320-H335
Precautionary statements	P264-P270-P301+P312-P330
WGK Germany	3

WS3 price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0758	WS3 ≥98% (HPLC)	1421227-52-2	25mg	$546	2023-01-07	Buy
Sigma-Aldrich	SML0758	WS3 ≥98% (HPLC)	1421227-52-2	5mg	$125	2022-05-15	Buy
Cayman Chemical	17667	WS-3 ≥95%	1421227-52-2	5mg	$62	2024-03-01	Buy
Cayman Chemical	17667	WS-3 ≥95%	1421227-52-2	10mg	$109	2024-03-01	Buy
Cayman Chemical	17667	WS-3 ≥95%	1421227-52-2	25mg	$254	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0758	25mg	$546	Buy
SML0758	5mg	$125	Buy
17667	5mg	$62	Buy
17667	10mg	$109	Buy
17667	25mg	$254	Buy

WS3 Chemical Properties,Uses,Production

Uses

WS3 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I.

Biological Activity

ws 3 is an agonist of trpm8 receptor with ec50 value of 3.7 μm [1].transient receptor potential cation channel subfamily m member 8 (trpm8) is a ca2+- and na+-permeable ion channel and is activated by cooling agents and cold temperatures. trpm8 belongs to trp family and is expressed in sensory neurons.ws 3 is an agonist of trpm8 receptor and a cooling agent. in hek293 cells expressed recombinant mouse trpm8, ws 3 (30 μm) increased [ca2+]i. ws 3 exhibited potency with ec50 value of 3.7 μm and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. in hek cells stably expressing either htrpm8 or htrpa1, ws 3 activated htrpm8 and htrpa1 with ec50 values of 2.2 and 120.6 μm, respectively. ws 3 was efficacious in eliciting cooling sensation [2].

References

[1]. behrendt hj, germann t, gillen c, et al. characterization of the mouse cold-menthol receptor trpm8 and vanilloid receptor type-1 vr1 using a fluorometric imaging plate reader (flipr) assay. br j pharmacol, 2004, 141(4): 737-745.
[2]. klein ah, iodi carstens m, mccluskey ts, et al. novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. chem senses, 2011, 36(7): 649-658.

WS3 Preparation Products And Raw materials

Raw materials

Preparation Products

WS3 Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19632	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aceschem Inc.	58

View Lastest Price from WS3 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	WS3 1421227-52-2	US $44.00-126.00 / mg		98.81%	10g	TargetMol Chemicals Inc.
	2019-09-06	N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE 1421227-52-2	US $1.00 / KG	1KG	95%	2kg	Career Henan Chemical Co

WS3
1421227-52-2
US $44.00-126.00 / mg
98.81%
TargetMol Chemicals Inc.

N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE
1421227-52-2
US $1.00 / KG
95%
Career Henan Chemical Co

WS3 Spectrum

WS3(1421227-52-2)¹HNMR

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N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide WS3 WS3 N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE WS3, 1421227-52-2 WS3, >=98% N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE WS-3; WS 3 CS-1800 Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]- N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)amino]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide WS3 USP/EP/BP insulin,pancreatic,pigment,WS3,proliferation,epithelial,β cell,WS 3,WS-3,Inhibitor,R7T1,diabete,RPE,inhibit,retinal WS3, 10 mM in DMSO 1421227-52-2 C28H30F3N7O3 Inhibitors api