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Z-VAD-FMK

Z-VAD-FMK Structure
Z-VAD-FMK structure
CAS No.
187389-52-2
Chemical Name:
Z-VAD-FMK
Synonyms
CS-2005;CS-1507;Z-VAD-FMK;HGNC:1504;Z-VAD(OME)-FMK;Z-VA(OME)D-FMK;Z-VADC(OME)-FMK;Z-VAD-FMK, >=98%;Z-VAL-ALA-ASP-FMK;CASPASE INHIBITOR I
CBNumber:
CB0203438
Molecular Formula:
C22H30FN3O7
Molecular Weight:
467.49
MDL Number:
MFCD03452883
MOL File:
Mol file
MSDS File:
SDS
Last updated:2024-11-01 18:09:03
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Z-VAD-FMK Properties

Melting point >190°C (dec.)
Boiling point 732.4±60.0 °C(Predicted)
Density 1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point 396.7℃
storage temp. -20°C
solubility DMSO: 20 mg/mL
form powder
pka 11.05±0.46(Predicted)
color white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey MIFGOLAMNLSLGH-QOKNQOGYSA-N
SMILES C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(OC)=O)C(=O)CF
CAS DataBase Reference 187389-52-2

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  22-24/25
WGK Germany  3
HS Code  29145090

Z-VAD-FMK price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V116 Z-VAD-FMK solid 187389-52-2 2mg $814 2024-03-01 Buy
Sigma-Aldrich SAB2501669 Anti-CASP3 antibody produced in goat affinity isolated antibody, buffered aqueous solution 187389-52-2 100μg $568 2024-03-01 Buy
Sigma-Aldrich 627610 Caspase Inhibitor I 187389-52-2 1mg $318 2024-03-01 Buy
Sigma-Aldrich 627610 Caspase Inhibitor I 187389-52-2 5mg $662 2024-03-01 Buy
Cayman Chemical 14463 Z-VAD(OMe)-FMK ≥95% 187389-52-2 1mg $100 2024-03-01 Buy
Product number Packaging Price Buy
V116 2mg $814 Buy
SAB2501669 100μg $568 Buy
627610 1mg $318 Buy
627610 5mg $662 Buy
14463 1mg $100 Buy

Z-VAD-FMK Chemical Properties,Uses,Production

Description

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

Uses

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Uses

Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.

Definition

ChEBI: Z-Val-Ala-Asp(OMe)-CH2F is a tripeptide consisting of Z-Val-Ala-Asp(OMe) in which the C-terminal OH group has been replaced by a fluoromethyl group. An irreversible pan-caspase inhibitor. It has a role as an apoptosis inhibitor and a protease inhibitor. It is a carbamate ester, a tripeptide and an organofluorine compound.

General Description

A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Biochem/physiol Actions

Cell permeable: yes

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

storage

-20°C

References

1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD-FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21 2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5 3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

Z-VAD-FMK Suppliers

Global( 209)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences
16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9220 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29886 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10310 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211 info@longyupharma.com China 2524 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32038 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
Supplier Advantage
BOC Sciences
58
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
TargetMol Chemicals Inc. 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58

View Lastest Price from Z-VAD-FMK manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-VAD(OMe)-FMK pictures 2024-11-01 Z-VAD(OMe)-FMK
187389-52-2
 US $52.00-247.00 / mg 99.41% 10g TargetMol Chemicals Inc.
Z-VAD-FMK pictures 2022-10-09 Z-VAD-FMK
187389-52-2
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
Z-VAD-FMK pictures 2019-07-06 Z-VAD-FMK
187389-52-2
 US $1.00 / KG 1G 98% 100KG Career Henan Chemical Co
  • Z-VAD(OMe)-FMK pictures
  • Z-VAD(OMe)-FMK
    187389-52-2
  • US $52.00-247.00 / mg
  • 99.41%
  • TargetMol Chemicals Inc.
  • Z-VAD-FMK pictures
  • Z-VAD-FMK
    187389-52-2
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • Z-VAD-FMK pictures
  • Z-VAD-FMK
    187389-52-2
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

Z-VAD-FMK Spectrum

Z-VAD-FMK(187389-52-2)1HNMR

187389-52-2(Z-VAD-FMK)Related Search:

Z-FA-FMK Z-DEVD-FMK Z-Vad-fmk, non-methylated 3-METHYLADENINE MK-2206 2HCl
Necrostatin-1 MG-132 LY 294002 HYDROCHLORIDE (2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoic acid PAC1
AC-DEVD-CHO AC-VDVAD-PNA Z-PHE-DL-ALA-FLUOROMETHYLKETONE Z-VAL-ALA-OH Z-VAL-TRP-OH
CBZ-L-VALINE METHYL ESTER Z-VAL-VAL-ARG-AMC Z-VAL-VAL-OH

1of4

Z-VADC(OME)-FMK methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-phenylmethoxycarbonylamino-butanoyl]amino]propanoyl]amino]-4-oxo-pentanoate N-BENZYLOXYCARBONYL-VAL-ALA-ASP FLUOROMETHYL KETONE Z-VAD-FLUOROMETHYLKETONE Z-VAD-FMK Z-VAD-FMK, METHYL ESTER Z-VAD(OME)-FLUOROMETHYLKETONE L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide z-vad -fmk Anti-CASP3 antibody produced in goat caspase 3, apoptosis-related cysteine peptidase caspase 3, apoptosis-related cysteine protease HGNC:1504 Z-VAD-FMK, >=98% Z-VAD(OME)-FMK Z-VAL-ALA-ASP-FLUOROMETHYLKETONE Z-VAL-ALA-ASP-FMK Z-VAL-ALA-ASP(OCH3)-FLUOROMETHYLKETONE Z-VAL-ALA-ASP(OME)-CH2F Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-VAL-ALA-ASP-(OME)-FMK Z-VAL-ALA-DL-ASP-FLUOROMETHYLKETONE Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE Z-VA(OME)D-FMK N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone BENZYLOXYCARBONYL-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE CARBOBENZOXY-VALYL-ALANYL-ASPARTYL-[O-METHYL]-FLUOROMETHYLKETONE CASPASE-1, INHIBITOR CASPASE-1 INHIBITOR VI (FLUOROMETHYLKETONE) CASPASE INHIBITOR I CASPASE INHIBITOR VI Z-VAD-FMK, Non-methylated PN: WO2005039629 PAGE: 18 claimed protein Z-VAD-FMK (Cell perMeable) 3: PN: WO0158526 SEQID: 3 claimed sequence N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide Z-VAD-FMK, 98%, an irreversible pan-caspase inhibitor Z-VAD(OME)-FMK;Z-VAL-ALA-ASP(OME)-FMK Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONEZ-Val-Ala-DL-Asp-fluoroMethylketone CS-2005 CS-1507 Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) Methyl (S)-3-[(S)-2-[(S)-2-(Cbz-amino)-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate (5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Z-VAD-FMK USP/EP/BP Caspase 3/7 Activity Assay Kit Methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Inhibitor,ZVAD(OMe)FMK,inhibit,Caspase,Z VAD(OMe) FMK Z-Val-Ala-Dl-Asp(Ome)-FMK 187389-52-2 67465-36-3 C22H30FN3O7 C21H28N3O7F C22H30N3O7F BioChemical Apoptosis and Cell Cycle Cell Biology Cell Signaling and Neuroscience