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3-METHYLADENINE

3-METHYLADENINE structure

CAS No.: 5142-23-4

Chemical Name:: 3-METHYLADENINE

Synonyms: 109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-

CBNumber:: CB9307216

Molecular Formula:: C6H7N5

Molecular Weight:: 149.15

MDL Number:: MFCD00010531

MOL File:: 5142-23-4.mol

Last updated:2024-11-12 08:58:12

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3-METHYLADENINE Properties

Melting point	~300 °C (dec.)(lit.)
Boiling point	240℃
Density	1.60
refractive index	1.8070 (estimate)
Flash point	99℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
pka	6.77±0.20(Predicted)
form	Powder
color	White
BRN	146087
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
EWG's Food Scores	1
FDA UNII	DR88TV7SNU

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c

Hazard Codes

Risk Statements

Safety Statements

24/25

WGK Germany

RTECS

AU6520000

HS Code

29335990

NFPA 704

	0
2		0

3-METHYLADENINE price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	189490	Autophagy Inhibitor, 3-MA	5142-23-4	50mg	$144	2024-03-01	Buy
Sigma-Aldrich	189490	Autophagy Inhibitor, 3-MA	5142-23-4	100mg	$159	2024-03-01	Buy
TCI Chemical	M2518	3-Methyladenine	5142-23-4	200mg	$141	2024-03-01	Buy
TCI Chemical	M2518	3-Methyladenine	5142-23-4	1g	$492	2024-03-01	Buy
Alfa Aesar	J64813	Autophagy Inhibitor, 3-MA	5142-23-4	25mg	$66.3	2023-06-20	Buy

Product number	Packaging	Price	Buy
189490	50mg	$144	Buy
189490	100mg	$159	Buy
M2518	200mg	$141	Buy
M2518	1g	$492	Buy
J64813	25mg	$66.3	Buy

3-METHYLADENINE Chemical Properties,Uses,Production

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

Chemical Properties

White powder

Uses

A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation

Uses

A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

Uses

3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

Definition

ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.

General Description

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC₅₀ = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

Biochem/physiol Actions

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

storage

+4°C

References

1) Seglen and Gordon?et al.?(1982),?3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA,?79?1889 2) Blommaart?et al. (1997),?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem.,?243?240 3) McFarland?et al. (2012),?Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol.,?86?275 4) Zhao?et al. (2014),?Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med.,?14?555

3-METHYLADENINE synthesis

Synthesis of 3-METHYLADENINE from Adenine-7-oxide

3-METHYLADENINE Preparation Products And Raw materials

Raw materials

Adenine Toluene Nickel Monoperoxyphthalic acid magnesium salt hexahydrate Benzyl bromide

N,N-Dimethylacetamide Sulfuric acid Dimethyl sulfate Adenosine, 2'-deoxy-,1-oxide (7CI,8CI,9CI) 3-Methyl Adenosine p-Toluenesulfonate Salt

Adenine-7-oxide 9-Methyladenine Iodomethane

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Preparation Products

1-METHYLADENINE

3-METHYLADENINE Suppliers

Global( 273)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10986	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20288	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29885	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8815	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
Zibo Hangyu Biotechnology Development Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hebei Weibang Biotechnology Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 3-METHYLADENINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-12	3-Methyladenine 5142-23-4	US $48.00-140.00 / mg		99.51%	10g	TargetMol Chemicals Inc.
2024-08-27	3-METHYLADENINE 5142-23-4	US $95.00-950.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2024-04-28	3-METHYLADENINE 5142-23-4	US $10.00-2.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

3-Methyladenine
5142-23-4
US $48.00-140.00 / mg
99.51%
TargetMol Chemicals Inc.

3-METHYLADENINE
5142-23-4
US $95.00-950.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

3-METHYLADENINE
5142-23-4
US $10.00-2.00 / KG
99%
Henan Fengda Chemical Co., Ltd

3-METHYLADENINE Spectrum

3-METHYLADENINE(5142-23-4)MS 3-METHYLADENINE(5142-23-4)¹HNMR 3-METHYLADENINE(5142-23-4)IR1 3-METHYLADENINE(5142-23-4)Raman

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3H-Purin-6-amine, 3-methyl- 3-methyl-3h-purin-6-amin 3-Methyl-3H-purin-6-amine 3-methyl-adenin Adenine, 3-methyl- 3-METHYLADENINE 3-methyl-3H-adenine 6-AMINO-3-METHYLPURINE 3-Methyladenine, 90+%, pure 3-Methyladenine, pure 3-Methyl-6-amino-3H-purine 3-Methyladenine6-Amino-3-methylpurine 3-Methyladenine, pure, 90+% 3-Methyl-6-aminopurine N3-Methyladenine NSC 66389 3-MA (3-Methyl adenine) 3-methyladenine,3MA NSC 66389,3-MA 3-Methyladenine, GC 90+% NSC 66389,3-M 6-Amino-3-methylpurine 3-Methyladenine Autophagy Inhibitor 3-Methyladenine, >=98% Autophagy Inhibitor, 3-MA Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem 109723 3-methylpurin-6-amine Methyladenine Methyladenine NSC-63889 3-METHYLADENINE USP/EP/BP N3-Methyladenine/NSC 66389 3-Methyl-6-am 5142-23-4 Building Blocks Biochemicals and Reagents BioChemical Heterocyclic Building Blocks Purines Nucleoside Analogs Nucleosides, Nucleotides, Oligonucleotides Akt mTOR PI3K Amines Bases & Related Reagents Heterocycles Inhibitors Nucleotides