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3-METHYLADENINE

CAS No.
5142-23-4
Chemical Name:
3-METHYLADENINE
Synonyms
109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
CBNumber:
CB9307216
Molecular Formula:
C6H7N5
Molecular Weight:
149.15
MDL Number:
MFCD00010531
MOL File:
5142-23-4.mol
Last updated:2024-11-19 20:33:22

3-METHYLADENINE Properties

Melting point ~300 °C (dec.)(lit.)
Boiling point 240℃
Density 1.60
refractive index 1.8070 (estimate)
Flash point 99℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
pka 6.77±0.20(Predicted)
form Powder
color White
BRN 146087
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
EWG's Food Scores 1
FDA UNII DR88TV7SNU

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c
Hazard Codes  Xn
Risk Statements  22
Safety Statements  24/25
WGK Germany  3
RTECS  AU6520000
HS Code  29335990
NFPA 704
0
2 0

3-METHYLADENINE price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 189490 Autophagy Inhibitor, 3-MA 5142-23-4 50mg $144 2024-03-01 Buy
Sigma-Aldrich 189490 Autophagy Inhibitor, 3-MA 5142-23-4 100mg $159 2024-03-01 Buy
TCI Chemical M2518 3-Methyladenine 5142-23-4 200mg $141 2024-03-01 Buy
TCI Chemical M2518 3-Methyladenine 5142-23-4 1g $492 2024-03-01 Buy
Alfa Aesar J64813 Autophagy Inhibitor, 3-MA 5142-23-4 25mg $66.3 2023-06-20 Buy
Product number Packaging Price Buy
189490 50mg $144 Buy
189490 100mg $159 Buy
M2518 200mg $141 Buy
M2518 1g $492 Buy
J64813 25mg $66.3 Buy

3-METHYLADENINE Chemical Properties,Uses,Production

Description

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy. 3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%. 3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.

Chemical Properties

White powder

Uses

A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation

Uses

A multi-use inhibitor that protects cerebellar granule cells from apoptosis.

Uses

3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

Definition

ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.

General Description

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)

Biochem/physiol Actions

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

storage

+4°C

References

1) Seglen and Gordon?et al.?(1982),?3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA,?79?1889 2) Blommaart?et al. (1997),?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem.,?243?240 3) McFarland?et al. (2012),?Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol.,?86?275 4) Zhao?et al. (2014),?Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med.,?14?555

21149-25-7
5142-23-4
Synthesis of 3-METHYLADENINE from Adenine-7-oxide
Global( 273)Suppliers
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Zibo Hangyu Biotechnology Development Co., Ltd
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View Lastest Price from 3-METHYLADENINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Methyladenine pictures 2024-11-19 3-Methyladenine
5142-23-4
US $48.00-140.00 / mg 99.51% 10g TargetMol Chemicals Inc.
3-METHYLADENINE pictures 2024-08-27 3-METHYLADENINE
5142-23-4
US $95.00-950.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
3-METHYLADENINE pictures 2024-04-28 3-METHYLADENINE
5142-23-4
US $10.00-2.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • 3-Methyladenine pictures
  • 3-Methyladenine
    5142-23-4
  • US $48.00-140.00 / mg
  • 99.51%
  • TargetMol Chemicals Inc.
  • 3-METHYLADENINE pictures
  • 3-METHYLADENINE
    5142-23-4
  • US $95.00-950.00 / kg
  • 0.99
  • Zibo Hangyu Biotechnology Development Co., Ltd
  • 3-METHYLADENINE pictures
  • 3-METHYLADENINE
    5142-23-4
  • US $10.00-2.00 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
3H-Purin-6-amine, 3-methyl- 3-methyl-3h-purin-6-amin 3-Methyl-3H-purin-6-amine 3-methyl-adenin Adenine, 3-methyl- 3-METHYLADENINE 3-methyl-3H-adenine 6-AMINO-3-METHYLPURINE 3-Methyladenine, 90+%, pure 3-Methyladenine, pure 3-Methyl-6-amino-3H-purine 3-Methyladenine6-Amino-3-methylpurine 3-Methyladenine, pure, 90+% 3-Methyl-6-aminopurine N3-Methyladenine NSC 66389 3-MA (3-Methyl adenine) 3-methyladenine,3MA NSC 66389,3-MA 3-Methyladenine, GC 90+% NSC 66389,3-M 6-Amino-3-methylpurine 3-Methyladenine Autophagy Inhibitor 3-Methyladenine, >=98% Autophagy Inhibitor, 3-MA Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem 109723 3-methylpurin-6-amine Methyladenine Methyladenine NSC-63889 3-METHYLADENINE USP/EP/BP N3-Methyladenine/NSC 66389 3-Methyl-6-am 5142-23-4 Building Blocks Biochemicals and Reagents BioChemical Heterocyclic Building Blocks Purines Nucleoside Analogs Nucleosides, Nucleotides, Oligonucleotides Akt mTOR PI3K Amines Bases & Related Reagents Heterocycles Inhibitors Nucleotides