3-METHYLADENINE
- CAS No.
- 5142-23-4
- Chemical Name:
- 3-METHYLADENINE
- Synonyms
- 109723;NSC 66389;NSC-63889;NSC 66389,3-M;3-Methyl-6-am;NSC 66389,3-MA;3-methyl-adenin;3-METHYLADENINE;N3-Methyladenine;Adenine, 3-methyl-
- CBNumber:
- CB9307216
- Molecular Formula:
- C6H7N5
- Molecular Weight:
- 149.15
- MDL Number:
- MFCD00010531
- MOL File:
- 5142-23-4.mol
Melting point | ~300 °C (dec.)(lit.) |
---|---|
Boiling point | 240℃ |
Density | 1.60 |
refractive index | 1.8070 (estimate) |
Flash point | 99℃ |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml). |
pka | 6.77±0.20(Predicted) |
form | Powder |
color | White |
BRN | 146087 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. |
EWG's Food Scores | 1 |
FDA UNII | DR88TV7SNU |
3-METHYLADENINE price More Price(47)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 189490 | Autophagy Inhibitor, 3-MA | 5142-23-4 | 50mg | $144 | 2024-03-01 | Buy |
Sigma-Aldrich | 189490 | Autophagy Inhibitor, 3-MA | 5142-23-4 | 100mg | $159 | 2024-03-01 | Buy |
TCI Chemical | M2518 | 3-Methyladenine | 5142-23-4 | 200mg | $141 | 2024-03-01 | Buy |
TCI Chemical | M2518 | 3-Methyladenine | 5142-23-4 | 1g | $492 | 2024-03-01 | Buy |
Alfa Aesar | J64813 | Autophagy Inhibitor, 3-MA | 5142-23-4 | 25mg | $66.3 | 2023-06-20 | Buy |
3-METHYLADENINE Chemical Properties,Uses,Production
Description
Autophagy is a multi-
Chemical Properties
White powder
Uses
A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation
Uses
A multi-use inhibitor that protects cerebellar granule cells from apoptosis.
Uses
3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
Definition
ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.
General Description
A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
Biochem/physiol Actions
3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).
storage
+4°C
References
1) Seglen and Gordon?et al.?(1982),?3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA,?79?1889 2) Blommaart?et al. (1997),?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem.,?243?240 3) McFarland?et al. (2012),?Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol.,?86?275 4) Zhao?et al. (2014),?Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med.,?14?555
3-METHYLADENINE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10977 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 3-METHYLADENINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-05-10 | 3-METHYLADENINE
5142-23-4
|
US $95.00-950.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
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2024-04-28 | 3-METHYLADENINE
5142-23-4
|
US $10.00-2.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
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2023-01-31 | 3-METHYLADENINE
5142-23-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 3-METHYLADENINE
5142-23-4
- US $95.00-950.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 3-METHYLADENINE
5142-23-4
- US $10.00-2.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-METHYLADENINE
5142-23-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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