Z-PHE-DL-ALA-FLUOROMETHYLKETONE
- CAS No.
- 197855-65-5
- Chemical Name:
- Z-PHE-DL-ALA-FLUOROMETHYLKETONE
- Synonyms
- CS-1504;Z-Phe-DL-Ala-FMK;Z-FA-FMK, 10 mM in DMSO;Z-PHE-DL-ALA-FLUOROMETHYLKETONE;Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide;Benzyl ((2S)-1-((4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate;Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide z-fa-fmk;Carbamic acid,N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester;SARS coronavirus,SARS-CoV,RRMs,DNA fragmentation,DEVDase,Caspase,Cathepsin,Inhibitor,externalization of phosphatidylserine,Apoptosis,inhibit,Z FA FMK,reovirus replication,ZFAFMK
- CBNumber:
- CB9710726
- Molecular Formula:
- C21H23FN2O4
- Molecular Weight:
- 386.42
- MDL Number:
- MFCD02684535
- MOL File:
- 197855-65-5.mol
| Boiling point | 630.5±55.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml |
| pka | 11.07±0.46(Predicted) |
| form | White solid |
| color | White to off-white |
| FDA UNII | 34O3P3306Z |
Z-PHE-DL-ALA-FLUOROMETHYLKETONE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14462 | Z-FA-FMK ≥98% | 197855-65-5 | 1mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 14462 | Z-FA-FMK ≥98% | 197855-65-5 | 5mg | $253 | 2024-03-01 | Buy |
| TRC | Z350000 | Z-FA-FMK | 197855-65-5 | 25mg | $790 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 49262 | Z-FA-FMK | 197855-65-5 | 5mg | $830 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0009036 | Z-PHE-DL-ALA-FLUOROMETHYLKETONE 98.00% | 197855-65-5 | 10MG | $1478.4 | 2021-12-16 | Buy |
Z-PHE-DL-ALA-FLUOROMETHYLKETONE Chemical Properties,Uses,Production
Description
Z-
Uses
Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.
in vivo
Z-FA-FMK (1 mg/kg; intratumor injection; every 2 d, for 27 d; SCID mice with HT1080 xenograft) blocks reovirus infection in vivo[2].
Z-FA-FMK (8 mg/kg; i.v.; every 2 d, once; male BALB/c mice) markedly lessens the degree of impairment seen in D-GalN/TNF-α-induced kidney injury[3].
| Animal Model: | SCID mice with HT1080 xenograft (6-8 weeks)[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intratumor injection; every 2 days, for 27 days |
| Result: | Blocked reovirus replication activity in both tumor and heart tissues. |
| Animal Model: | Male BALB/c mice[3] |
| Dosage: | 8 mg/kg |
| Administration: | Intravenous injection; once, 1 hour later, intraperitoneal injection D-GalN (700 mg/kg) and TNF-α (15 μg/kg). |
| Result: | Decreased in the D-GalN/TNF-α-induced degenerative changes. Decreased in the number of activated caspase-3-positive tubular epithelial cell. Increased in kidney GSH levels, CAT, SOD and GPx activities and decreased in kidney LPO levels, LDH activity, serum AST and ALT activities, uric acid, and urea levels were determined. |
IC 50
Cathepsin B; cathepsin L; Caspase-2; Caspase-3; Caspase-6; Caspase-7
Z-PHE-DL-ALA-FLUOROMETHYLKETONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32200 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
