ARCYRIAFLAVIN A
- CAS No.
- 118458-54-1
- Chemical Name:
- ARCYRIAFLAVIN A
- Synonyms
- ARCYRIAFLAVIN A;ARCYRIAFLAVIN A, SYNTHETIC;12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-
- CBNumber:
- CB5311390
- Molecular Formula:
- C20H11N3O2
- Molecular Weight:
- 325.32
- MDL Number:
- MFCD03452662
- MOL File:
- 118458-54-1.mol
ARCYRIAFLAVIN A price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13516 | Arcyriaflavin A ≥95% | 118458-54-1 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 13516 | Arcyriaflavin A ≥95% | 118458-54-1 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 13516 | Arcyriaflavin A ≥95% | 118458-54-1 | 10mg | $220 | 2024-03-01 | Buy |
| Tocris | 2457 | ArcyriaflavinA ≥98%(HPLC) | 118458-54-1 | 10 | $223 | 2021-12-16 | Buy |
| TRC | A766578 | ArcyriaflavinA | 118458-54-1 | 2.5mg | $520 | 2021-12-16 | Buy |
ARCYRIAFLAVIN A Chemical Properties,Uses,Production
Uses
Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1.
Definition
ChEBI: LSM-3627 is an indolocarbazole.
Biological Activity
Potent inhibitor of cdk4/cyclin D1 (IC 50 = 59 nM). Also active against CaM kinase II (IC 50 = 25 nM) but displays selectivity over several other kinases in vitro (IC 50 values for inhibition of PKA and PKC are > 2 and > 100 μ M respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC 50 = 200 nM).
in vitro
arcyriaflavin a is a potent, selective inhibitor of hcmv replication in cell culture, and the anti-hcmv activity appeared no relation to the inhibition of protein kinase c. the imide nh was identified to be essential for anti-hcmv activity [1]. arcyriaflavin a also has been showed the inhibitory activity against d1/cdk4 with a ic50 of 59 nm. based on x-ray co-crystal structure of staurosporine and the human cdk2, the acidic proton of the maleimide moiety and the carbonyl group play critical roles by acting as a hydrogen bond donor and acceptor in the atp binding pocket of cdk2 [2].
IC 50
0.2 μm for hcmv [1], 0.14 μm for d1–cdk4 [2]
References
[1] slater mj, cockerill s, baxter r, bonser rw, gohil k, gowrie c, robinson je, littler e, parry n, randall r, snowden w. indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. bioorg med chem. 1999 jun;7(6):1067-74.
[2] zhu g, conner s, zhou x, shih c, brooks hb, considine e, dempsey ja, ogg c, patel b, schultz rm, spencer cd, teicher b, watkins sa. synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin d1/cdk4 inhibitors. bioorg med chem lett. 2003 apr 7;13(7):1231-5.
ARCYRIAFLAVIN A Preparation Products And Raw materials
ARCYRIAFLAVIN A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Synchem OHG | +49 5662 408730 | info@synchem.de | Germany | 4705 | 70 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 5002 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7296 | 58 |
View Lastest Price from ARCYRIAFLAVIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-11 | Arcyriaflavin A
118458-54-1
|
US $61.00-147.00 / mg | 97.68% | 10g | TargetMol Chemicals Inc. |
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- Arcyriaflavin A
118458-54-1
- US $61.00-147.00 / mg
- 97.68%
- TargetMol Chemicals Inc.