p38 MAP Kinase Inhibitor III
- CAS No.
- 581098-48-8
- Chemical Name:
- p38 MAP Kinase Inhibitor III
- Synonyms
- (S)-p38 MAPK Inhibitor III;(S)-p38 MAP Kinase Inhibitor III;p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem;(S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III;4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine;2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-
- CBNumber:
- CB53136792
- Molecular Formula:
- C23H21FN4S
- Molecular Weight:
- 404.5
- MDL Number:
- MFCD09037547
- MOL File:
- 581098-48-8.mol
- MSDS File:
- SDS
| Melting point | 117-119 °C |
|---|---|
| Boiling point | 589.4±60.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | DMF: 20 mg/mL; DMSO: 12 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/mL |
| form | Yellow solid |
| pka | 9.07±0.10(Predicted) |
| color | White to off-white |
p38 MAP Kinase Inhibitor III price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 506121 | p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem | 581098-48-8 | 1mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 19696 | (S)-p38 MAPK Inhibitor III ≥98% | 581098-48-8 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 19696 | (S)-p38 MAPK Inhibitor III ≥98% | 581098-48-8 | 1mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 19696 | (S)-p38 MAPK Inhibitor III ≥98% | 581098-48-8 | 5mg | $535 | 2024-03-01 | Buy |
| Cayman Chemical | 19696 | (S)-p38 MAPK Inhibitor III ≥98% | 581098-48-8 | 10mg | $936 | 2024-03-01 | Buy |
p38 MAP Kinase Inhibitor III Chemical Properties,Uses,Production
Description
(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively).
General Description
A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC50 = 0.38 μM for p38α). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC50 = 0.16 and 0.039 μM for TNF-α and IL-1β release, respectively, in human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-α release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 μl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available.
Biochem/physiol Actions
Cell permeable: yes
p38 MAP Kinase Inhibitor III Preparation Products And Raw materials
Raw materials
Preparation Products
p38 MAP Kinase Inhibitor III Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | hanfangpharma@126.com | China | 30968 | 58 |