p38 MAP Kinase Inhibitor III

p38 MAP Kinase Inhibitor III Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC₅₀s = 0.37 and 0.044 μM, respectively).

Allgemeine Beschreibung

A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC₅₀ = 0.38 μM for p38α). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC₅₀ = 0.16 and 0.039 μM for TNF-α and IL-1β release, respectively, in human PBMC) and in vivo (ED₅₀ = 1.33 mg/kg for TNF-α release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 μl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes

p38 MAP Kinase Inhibitor III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

p38 MAP Kinase Inhibitor III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11975	58
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	hanfangpharma@126.com	China	30968	58

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• p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
• (S)-p38 MAPK Inhibitor III
• 2-Pyridinamine, 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-
• (S)-p38 MAP Kinase Inhibitor III
• (S)-p-38 MAPK Inhibitor III,(S) p38 MAPK Inhibitor III,(S)p38 MAPK Inhibitor III
• 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamine
• 581098-48-8