CARIPORIDE
- CAS No.
- 159138-80-4
- Chemical Name:
- CARIPORIDE
- Synonyms
- CS-1692;CARIPORIDE;Cariporide (HOE-642);N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide;BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-;Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642
- CBNumber:
- CB5324031
- Molecular Formula:
- C12H17N3O3S
- Molecular Weight:
- 283.35
- MDL Number:
- MFCD00864683
- MOL File:
- 159138-80-4.mol
- MSDS File:
- SDS
Melting point | 90-94° (dec) |
---|---|
Density | 1.34 |
storage temp. | 2-8°C |
solubility | insoluble in H2O; ≥12.05 mg/mL in DMSO; ≥2.675 mg/mL in EtOH with gentle warming and ultrasonic |
form | powder |
color | white to beige |
FDA UNII | 7E3392891K |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
RTECS | CV2310560 |
CARIPORIDE price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1360 | Cariporide ≥98% (HPLC) | 159138-80-4 | 5mg | $85.5 | 2024-03-01 | Buy |
Sigma-Aldrich | SML1360 | Cariporide ≥98% (HPLC) | 159138-80-4 | 25mg | $205.2 | 2024-03-01 | Buy |
Cayman Chemical | 16935 | Cariporide ≥95% | 159138-80-4 | 5mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 16935 | Cariporide ≥95% | 159138-80-4 | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 16935 | Cariporide ≥95% | 159138-80-4 | 50mg | $477 | 2024-03-01 | Buy |
CARIPORIDE Chemical Properties,Uses,Production
Uses
Reduction of death and nonfatal myocardial infarction in patients undergoing CABG surgery.
Uses
Cariporide is an Na+/H+ exchange inhibitor that functions to improve cellular integrity following events of cardiac ischemia and reperfusion (most commonly seen in non-heart beating donor organs). Cariporide is also used to prevent heart attacks in high-risk ischemic patients.
Biological Activity
na–h exchange (nhe) represents an important mechanism for mediating such injury. nhe represents an important mechanism for the development of myocardial ischemic and reperfusion injury and inhibitors have been consistently shown to protect the ischemic and reperfused heart by correcting the ionic imbalance associated with this form of pathological insult. cariporide is a potent nhe inhibitor.
Biochem/physiol Actions
Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. Cariporide has shown cardioprotective and antiarrhythmic effects, and has recently been investigated for anticancer activity.
in vitro
cariporide concentration dependently inhibited the amiloride sensitive sodium influx in rabbit erythrocytes, reduced the swelling of human platelets caused by intracellular acidification, and delayed ph recovery in rat cardiomyocytes [1].
in vivo
in anaesthetised rats undergoing coronary artery ligation intravenous and oral pretreatment with cariporide caused a dose dependent reduction or a complete prevention of ventricular premature beats, ventricular fibrillation, and ventricular tachycardia. the compound was well tolerated and neutral to circulatory variables [1].
IC 50
0.05, 3 and 1000 μm for nhe1, nhe3 and nhe2, respectively
storage
Store at +4°C
CARIPORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CARIPORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29898 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
View Lastest Price from CARIPORIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | CARIPORIDE
159138-80-4
|
US $1.00 / KG | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
- CARIPORIDE
159138-80-4
- US $1.00 / KG
- 98%
- Career Henan Chemical Co