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3-Mercapto-1,2-propanediol

3-Mercapto-1,2-propanediol Structure
3-Mercapto-1,2-propanediol structure
CAS No.
96-27-5
Chemical Name:
3-Mercapto-1,2-propanediol
Synonyms
MONOTHIOGLYCEROL;1-THIOGLYCEROL;THIOGLYCEROL;1-Mercaptoglycerol;3-Mercaptopropane-1,2-diol;ALPHA-THIOGLYCEROL;THIOGLYCERIN;A-MONOTHIOGLYCEROL;1-Mercapto-2,3-propanediol;Thiovanol
CBNumber:
CB5325331
Molecular Formula:
C3H8O2S
Molecular Weight:
108.16
MDL Number:
MFCD00004879
MOL File:
96-27-5.mol
MSDS File:
SDS
Last updated:2024-08-13 17:19:14
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3-Mercapto-1,2-propanediol Properties

Melting point <25 °C
Boiling point 118 °C5 mm Hg(lit.)
Density 1.25 g/mL at 25 °C(lit.)
vapor pressure <1 hPa (20 °C)
refractive index n20/D 1.527(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility absolute ethanol: 1 mL/mL
pka pK1:9.43 (25°C,μ=0.5)
form liquid
color Clear colorless to yellow
PH 3.5-7.0
Odor Stench odour
Water Solubility slightly soluble
Sensitive Air Sensitive & Hygroscopic
Merck 14,9335
BRN 1732046
Stability Air Sensitive, Hygroscopic
InChIKey PJUIMOJAAPLTRJ-UHFFFAOYSA-N
LogP -0.84 at 20℃
CAS DataBase Reference 96-27-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII AAO1P0WSXJ
NIST Chemistry Reference Monothioglycerol(96-27-5)
EPA Substance Registry System 1,2-Propanediol, 3-mercapto- (96-27-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H302-H311-H315-H317
Precautionary statements  P280-P301+P312+P330-P302+P352+P312
Hazard Codes  Xn,Xi
Risk Statements  21/22-36/37/38
Safety Statements  26-36-23
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  TY8140000
F  3-9-10-13-23
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29309070
NFPA 704
1
2 1

3-Mercapto-1,2-propanediol price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 50mL $121 2024-03-01 Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 250ML $326 2024-03-01 Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 1L $588 2024-03-01 Buy
TCI Chemical S0374 alpha-Thioglycerol [Matrix for FABMS and liquid SIMS] >98.0%(GC)(T) 96-27-5 1g $24 2024-03-01 Buy
TCI Chemical S0374 alpha-Thioglycerol [Matrix for FABMS and liquid SIMS] >98.0%(GC)(T) 96-27-5 10g $95 2024-03-01 Buy
Product number Packaging Price Buy
8.41705 50mL $121 Buy
8.41705 250ML $326 Buy
8.41705 1L $588 Buy
S0374 1g $24 Buy
S0374 10g $95 Buy

3-Mercapto-1,2-propanediol Chemical Properties,Uses,Production

Description

1-Thioglycerol is a reagent used in fluorescence, spectroscopy, and microbiology techniques. Varying the concentration of 1-thioglycerol in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration. It is used as a capping agent in the synthesis of nanocrystals analyzed via Raman and UV/Vis spectroscopy. Biologically, 1-thioglycerol stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in E. coli grown in an aerobic environment. It was previously a component in hair permanents used to produce waves or curls.

Chemical Properties

clear colorless to yellowish viscous solution

Chemical Properties

Monothioglycerol occurs as a colorless or pale-yellow colored, viscous, hygroscopic liquid with a slight odor of sulfide.

Uses

It generally used as a size-regulating capping agent for nanocrystals. 1-Thioglycerol is also used in bacteriology experiments to induce the synthesis of porphyrin compounds in aerobically growing Escherichia coli. Also used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals. 1-Thioglycerol is used to develop and test thiol functionalized copolymers. 1-Thioglycerol is used as a post-modification agent in the generation of non-standard peptide foldamers.Potential substitute for 2-mercaptoethanol, probe for the study of lymphocyte activation.

Uses

3-Mercapto-1,2-propanediol can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research. Matrix substrate in fast atom bombardment mass spectrometry.

Uses

3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding

Production Methods

Monothioglycerol is prepared by heating an ethanolic solution of 3- chloro-1,2-propanediol with potassium bisulfide.

Definition

ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.

General Description

1-Thioglycerol stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. It is an inhibitor of glycerol kinase activity in vitro and in situ.

Pharmaceutical Applications

Monothioglycerol is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations.Monothioglycerol is reported to have some antimicrobial activity.It is also widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02% w/w aqueous solution to stimulate wound healing, and as a 0.1% w/w jelly in atrophic rhinitis.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Mutation data reported. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits hghly toxic fumes of SOx.

Safety

Monothioglycerol is generally regarded as a relatively nontoxic and nonirritant material at the concentrations used as a pharmaceutical excipient. It is used in topical and injectable preparations. Undiluted monothioglycerol is considered a poison by the IP and IV routes; it has also been reported to be mutagenic.
LD50 (cat, IV): 0.22 g/kg
LD50 (mouse, IP): 0.34 g/kg
LD50 (rabbit, IV): 0.25 g/kg
LD50 (rat, IP): 0.39 g/kg

storage

Monothioglycerol is unstable in alkaline solutions. Monothioglycerol should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Monothioglycerol can react with oxidizing materials.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM, IV and other injections). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

3-Mercapto-1,2-propanediol Preparation Products And Raw materials

Raw materials

Glycerol Impurity (Disulfide Oxidation Product) Glycidol Thioacetic acid 3-Chloro-1,2-propanediol

Preparation Products

3-Mercapto-1,2-propanediol Suppliers

Global( 331)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Guangzhou CATO Research Chemicals Inc.
+86-020-81960175-620 +8618520203721 huan.li@cato-chem.com China 3880 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12837 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5893 58
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@sdzhonghuimaterial.com China 983 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3002 58
Shandong Deshang Chemical Co., Ltd. 		+86-0531-8875-2665 +8613153039501 info@deshangchem.com China 660 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18648 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd
58
Aladdin Scientific
58
Guangzhou CATO Research Chemicals Inc.
58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
airuikechemical co., ltd. 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Shandong Deshang Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

Related articles

View Lastest Price from 3-Mercapto-1,2-propanediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Mercapto-1,2-propanediol pictures 2024-11-01 3-Mercapto-1,2-propanediol
96-27-5
 US $75.00-20.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
3-Mercapto-1,2-propanediol pictures 2024-10-23 3-Mercapto-1,2-propanediol
96-27-5
 US $8.90-5.20 / kg 1kg 99% 10 tons Shandong Deshang Chemical Co., Ltd.
3-Mercapto-1,2-propanediol pictures 2024-10-15 3-Mercapto-1,2-propanediol
96-27-5
 US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.

3-Mercapto-1,2-propanediol Spectrum

3-Mercapto-1,2-propanediol(96-27-5)MS3-Mercapto-1,2-propanediol(96-27-5)1HNMR3-Mercapto-1,2-propanediol(96-27-5)IR13-Mercapto-1,2-propanediol(96-27-5)Raman

96-27-5(3-Mercapto-1,2-propanediol)Related Search:

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2-Mercaptoethanol Malathion Octyl thioglucoside

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MERCAPTOGLYCEROL 1-Thioglycerol,α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol 2,3-Dihydroxypropane-1-thiol, 3-Sulfanylpropane-1,2-diol, Mercapto glycerol, Thioglycerol 3-Thiopropane-1,2-diol, NF grade alpha-Thioglycerol  3-Mercapto-1,2-propanediol, 90 wt% aqueous solution 100ML 3-Mercapto-1,2-propanediol, 90 wt% aqueous solution 25ML 3-Thiopropane-1,2-diol 97% Thioglycerol, 3-Mercaptopropane-1,2-diol 2,3-Dihydroxypropane-1-thiol, 3-Sulphanylpropane-1,2-diol, Mercapto glycerol, Thioglycerol 1-Thioglycerol 〔3-Mercapto-1,2-Propanediol〕 α-Thioglycerol [Matrix for FABMS and liquid SIMS] 3-Mercapto-1,2-propanediol for synthesis MONOTHIOGLYCEROL, CELL CULTURE TESTED 1-THIOGLYCEROL, MATRIX SUBSTANCE FOR FAB -MS 1-THIOGLYCEROL 90 % IN WATER 1-THIOGLYCEROL, DIST. A-MONOTHIOGLYCEROL SIGMAULTRA 3-MERCAPTO-1,2-PROPANEDIOL 90 WT% AQUEOUS SOLUTION 3-MERCAPTO-1,2-PROPANEDIOL, MIN. 98%, REAGENT GRADE 1-Thioglycerol,>89% 3-Mercapto-1,2-propanediol, tech., 90% 1-THIOGLYCEROL GR 90% 3-MERCAPTO-1,2-PROPANEDIOL(1-THIOGLYCEROL)) 3-THIOGLYCEROL 3-MERCAPTO-1,2-PROPANEDIOL 90+% alpha-Thioglycerol [Matrix for FABMS and liquid SIMS] 3-MERCAPTO-1,2-PROPANEDIOL pure α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol 3-Sulfanylpropane-1,2-diol Mercapto-1,2-propanediol 3-MERCAPTO-1,2-PROPANEDIOLRESEARCH GRADE ALPHA-MONOTHIOGLYCEROL 3-MERCAPTO-1,2-PROPANDIOL 3-MERCAPTO-1,2-PROPANEDIOL 1,2-Propanediol, 3-mercapto- 1-Monothioglycerol 1-Thio-2,3-propanediol 1-Thiogylcerol 2,3-Dihydroxypropanethiol 3-mercapto-propane-1,2-diol 3-Sulfanyl-1,2-propanediol alpha-Thiolglycerol Glycerol, 1-thio- Glycerol-1-thiol Monothioglycerin Thioglycerine Thiovanol USAF B-40 USAF cb-37 rac-3-sulfanylpropane-1,2-diol Mono Thioglycerol (MTG) 3-Thiopropane-1,2-diol α-Thioglycerol[MatrixforFABMSandliquidSIMS]> α-Thioglycerol Monothioglycerol USP-NF PARENTEX 100GM Monothioglycerol USP-NF PARENTEX 500GM Monothioglycerol USP-NF PARENTEX 1KG