ANTI-TCF-4
- CAS No.
- Chemical Name:
- ANTI-TCF-4
- Synonyms
- ANTI-TCF-4;MONOCLONAL ANTI-TCF-4 (T-CELL FACTOR-4);Anti-TCF7L2 (ab1) antibody produced in rabbit;Anti-TCF7L2 (ab2) antibody produced in rabbit;Anti-Transcription factor 7-like 2 (T-cell specific, HMG-box);Monoclonal Anti-TCF-4 (T-Cell Factor-4) antibody produced in mouse
- CBNumber:
- CB5325351
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02097475
- MOL File:
- Mol file
ANTI-TCF-4 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB2102397 | Anti-TCF7L2 (ab2) antibody produced in rabbit affinity isolated antibody | 100μL | $524 | 2024-03-01 | Buy | |
| Sigma-Aldrich | T5817 | Monoclonal Anti-TCF-4 (T-Cell Factor-4) antibody produced in mouse ~1?mg/mL, clone 6H5-3, purified immunoglobulin, buffered aqueous glycerol solution | 0.1MG | $668 | 2023-06-20 | Buy | |
| American Custom Chemicals Corporation | ATB0018278 | ANTI-TCF4 95.00% | 5MG | $505.99 | 2021-12-16 | Buy |
ANTI-TCF-4 Chemical Properties,Uses,Production
Uses
May be used for gel-shift assays
General Description
Transcription factor 4 or T-Cell Factor-4 (TCF-4), also called as transcription factor 7 like 2 (TCF7L2), is mapped to human chromosome 18q21.1. The gene codes for a basic helix-loop-helix DNA binding protein, which belongs to TCF family and is implicated in transcriptional regulation. It is expressed predominantly in nervous system. TCF4 protein has a transcriptional activation domain 2 (AD2), a transcriptional activation domain (AD1) and a nuclear localization signal (NLS) in the N-terminal end and a C-terminal basic helix-loop-helix (bHLH) domain, involved in dimerization and deoxyribonucleic acid (DNA) binding.
Biochem/physiol Actions
Transcription factor 4 (TCF-4) interacts functionally with β-catenin to mediate Wnt signaling pathway and transactivates downstream target genes implicated in cancer development. TCF-4 plays a vital role in development of the nervous system and vertebrate development. Aberrations or mutation of the gene leads to Pitt-Hopkins syndrome (PTHS), a rare developmental disorder characterized by severe motor and mental retardation, typical facial features and breathing abnormalities.
ANTI-TCF-4 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-TCF-4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| Kamiya Biomedical Company | -- | ordering@kamiyabiomedical.com | United States | 736 | 72 |
| Upstate | -- | info@upstate.com | United States | 876 | 76 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| Kamiya Biomedical Company | 72 |
| Upstate | 76 |