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PF-6260933

PF-6260933 structure

CAS No.: 1811510-56-1

Chemical Name:: PF-6260933

Synonyms: PF-6260933;PF06260933;5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine;[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-;PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933;inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933

CBNumber:: CB53344890

Molecular Formula:: C16H13ClN4

Molecular Weight:: 296.75

MDL Number:: MFCD30532622

MOL File:: 1811510-56-1.mol

Last updated:2024-11-19 20:33:22

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PF-6260933 Properties

Boiling point	483.8±40.0 °C(Predicted)
Density	1.330±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form	A solid
pka	5.04±0.13(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933998090

PF-6260933 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-8001	PF-06260933 98.41%	1811510-56-1	5mg	$144	2021-12-16	Buy
ChemScene	CS-8001	PF-06260933 98.41%	1811510-56-1	10mg	$228	2021-12-16	Buy
ChemScene	CS-8001	PF-06260933 98.41%	1811510-56-1	25mg	$468	2021-12-16	Buy
ChemScene	CS-8001	PF-06260933 98.41%	1811510-56-1	50mg	$660	2021-12-16	Buy
ChemScene	CS-8001	PF-06260933 98.41%	1811510-56-1	100mg	$1020	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-8001	5mg	$144	Buy
CS-8001	10mg	$228	Buy
CS-8001	25mg	$468	Buy
CS-8001	50mg	$660	Buy
CS-8001	100mg	$1020	Buy

PF-6260933 Chemical Properties,Uses,Production

Biological Activity

PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.

in vitro

PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.

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in vivo

In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.

target

Target	Value
MAP4K4 ()	3.7 nM

PF-6260933 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-6260933 Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4512	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8011	62

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62

View Lastest Price from PF-6260933 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	PF-06260933 1811510-56-1	US $42.00-105.00 / mg		99.97%	10g	TargetMol Chemicals Inc.

PF-06260933
1811510-56-1
US $42.00-105.00 / mg
99.97%
TargetMol Chemicals Inc.

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PF-6260933 [3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)- PF06260933 PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933 inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine 1811510-56-1