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Isosilybin

Isosilybin structure

CAS No.: 72581-71-6

Chemical Name:: Isosilybin

Synonyms: Q-100795;Isosilybin;ISOSILIBININ;Isosilybinin;indissolubly;Isosilybin，ISB;ISOSILYBIN hplc;Diosmin Impurity 24;Isosilybin USP/EP/BP;Isosilybin(Mixture A&B)

CBNumber:: CB5359479

Molecular Formula:: C25H22O10

Molecular Weight:: 482.44

MDL Number:: MFCD09842608

MOL File:: 72581-71-6.mol

Last updated:2025-01-27 09:38:02

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Isosilybin Properties

Boiling point	793.0±60.0 °C(Predicted)
Density	1.527±0.06 g/cm3(Predicted)
storage temp.	Store at -20° C
solubility	DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.1 mg/ml
pka	7.39±0.60(Predicted)
form	Solid
color	White-light yellow
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312+P330-P501

NFPA 704

	0
2		0

Isosilybin price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL89231	Isosilybin (A + B mixture) phyproof? Reference Substance	72581-71-6	10MG	$732	2024-03-01	Buy
Cayman Chemical	24913	Isosilybin ≥95%	72581-71-6	1mg	$242	2024-03-01	Buy
Cayman Chemical	24913	Isosilybin ≥95%	72581-71-6	5mg	$1087	2024-03-01	Buy
Cayman Chemical	24913	Isosilybin ≥95%	72581-71-6	10mg	$2052	2024-03-01	Buy
Usbiological	280565	Isosilybin	72581-71-6	5mg	$595	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHL89231	10MG	$732	Buy
24913	1mg	$242	Buy
24913	5mg	$1087	Buy
24913	10mg	$2052	Buy
280565	5mg	$595	Buy

Isosilybin Chemical Properties,Uses,Production

Structure

Only silybins and isosilybins contain the 1,4-dioxane ring system in their structure during Silymarin’s primary constituents. Silybin and isosilybin have the same trans conformation of C-2, C-3, C-7′ and C-8′. Silybin is considered the major and most active component of silymarin.

Description

Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC₅₀ = 32 μM) and reduces ADP/Fe³⁺-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

Uses

Isosilybin is useful in the treatment of liver disease

Definition

The flavonolignan isosilybin is one of the components of the flavonoid complex extracted from the seeds of Silybum marianum (milk thistle), designated silymarin. Besides isosilybin, silymarin contains other flavonoids (congeners), such as silybin, 2,3-dehydrosilybin, silydianin, silychristin, isosilychristin, and taxifolin and ca. 20–30% is an undefined polymeric phenolic fraction. However, several recent studies have demonstrated that isosilybin is probably the most potent anticancer agent in silymarin. Isosilybin was shown to possess in vivo anti-proliferative, anti-angiogenic, pro-apoptotic, and cell-cycle modulatory properties. Moreover, isosilybin and especially isosilybin B inhibited the growth of advanced human prostate cancer cells in vivo without any toxic effects[1].

Definition

ChEBI: A flavonolignan isolated from Silybum marianum.

References

[1] Radek Ga?ák . “Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture.” Process Biochemistry 48 1 (2013): Pages 184-189.

Isosilybin Preparation Products And Raw materials

Raw materials

Preparation Products

Isosilybin Suppliers

Global( 177)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3772	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49476	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29809	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Shanghai Standard Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from Isosilybin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Isosilybin 72581-71-6	US $30.00-105.00 / mg		98%	10g	TargetMol Chemicals Inc.
2024-03-28	Isosilybin 72581-71-6	US $0.00 / kg	25kg	30% 50%(HPLC) 80%(UV)	Inquiry	PNP Biotech Co. Ltd
2023-02-24	Isosilybin 72581-71-6	US $0.00 / mg	20mg	≥98%(HPLC)	100 g	Shanghai Standard Technology Co., Ltd.

Isosilybin
72581-71-6
US $30.00-105.00 / mg
98%
TargetMol Chemicals Inc.

Isosilybin
72581-71-6
US $0.00 / kg
30% 50%(HPLC) 80%(UV)
PNP Biotech Co. Ltd

Isosilybin
72581-71-6
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

72581-71-6(Isosilybin)Related Search:

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ISOSILIBININ ISOSILYBIN(PRIMARY STANDARD) Isosilybinin (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one ISOSILYBIN hplc Isosilybin (A+B) mixture -(2,3-Dihydro-2-(4-hydroxy-3-Methoxyphenyl)-3-(hydroxyMethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one Isosilybin 4H-1-Benzopyran-4-one,2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)- Isosilybin (Isosilybinin) Q-100795 Isosilybin (Mixture of Diastereomers) Isosilybin，ISB Isosilybin USP/EP/BP indissolubly Isosilybin(Mixture A&B) Diosmin Impurity 24 (2R,3R)-3,5,7-Trihydroxy-2-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one Isosilybin, 10 mM in DMSO 72581-71-6 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Miscellaneous Natural Products Intermediates & Fine Chemicals Pharmaceuticals