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SB 431542

SB 431542 structure

CAS No.: 301836-41-9

Chemical Name:: SB 431542

Synonyms: CS-89;SB 431542;SB 431542, >=98%;SB 431542 HYDRATE;SB-431542/SB431542;SB 431542USP/EP/BP;TGF-β RI Kinase Inhibitor VI, SB431542;TGF-β RI Kinase Inhibitor VI SB431542 SB-431542;InSolution? TGF-β RI Kinase Inhibitor VI, SB431542;4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid

CBNumber:: CB5360318

Molecular Formula:: C22H16N4O3

Molecular Weight:: 384.39

MDL Number:: MFCD05865244

MOL File:: 301836-41-9.mol

MSDS File:: SDS

Last updated:2024-11-18 17:01:59

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SB 431542 Properties

Melting point	214 °C(dec.)
Boiling point	662.4±55.0 °C(Predicted)
Density	1.373
Flash point	354.4℃
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 10 mg/mL, soluble
form	powder
pka	10.14±0.10(Predicted)
color	Yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey	FHYUGAJXYORMHI-UHFFFAOYSA-N
FDA UNII	E1557V1V0N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338-P362+P364
Safety Statements	22-24/25
WGK Germany	3
HS Code	29349990

SB 431542 price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	616464	InSolution? TGF-β RI Kinase Inhibitor VI, SB431542	301836-41-9	5mg	$159	2024-03-01	Buy
Sigma-Aldrich	616461	TGF-β RI Kinase Inhibitor VI, SB431542	301836-41-9	5mg	$176	2024-03-01	Buy
TCI Chemical	B4003	SB 431542	301836-41-9	25MG	$241	2024-03-01	Buy
TCI Chemical	B4003	SB 431542	301836-41-9	100MG	$662	2024-03-01	Buy
Cayman Chemical	13031	SB 431542 ≥98%	301836-41-9	1mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
616464	5mg	$159	Buy
616461	5mg	$176	Buy
B4003	25MG	$241	Buy
B4003	100MG	$662	Buy
13031	1mg	$32	Buy

SB 431542 Chemical Properties,Uses,Production

Description

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It is a less potent antagonist of ALK4 (IC₅₀ = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

Uses

SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells. Potent TGF-beta inhibitor.

Definition

ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.

General Description

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 μM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC₅₀ = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC₅₀ ≥10 μM in the presence of 10 μM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).

Biological Activity

Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.

Biochem/physiol Actions

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

storage

Room temperature

References

1) Laping et al. (2002), Inhibition of transforming growth factor (TGF-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I kinase activity: SB-431542; Mol. Pharmacol., 62 58 2) Inman et al. (2002), SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5 and ALK7; Mol. Pharmacol., 62 65 3) Matsuyama et al. (2003), SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells; Cancer Res., 63 7791 4) Watabe et al. (2003), TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells; J. Cell Biol., 163 1303 5) Stanslowsky et al. (2014), Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells; Stem Cell Res. Ther., 5 35

SB 431542 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 431542 Suppliers

Global( 205)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9214	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from SB 431542 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-18	SB-431542 301836-41-9	US $50.00-296.00 / mg		99.87%	10g	TargetMol Chemicals Inc.

SB-431542
301836-41-9
US $50.00-296.00 / mg
99.87%
TargetMol Chemicals Inc.

SB 431542 Spectrum

SB 431542(301836-41-9)MS

301836-41-9(SB 431542)Related Search:

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MG-132 LDN-193189 LY 294002 HYDROCHLORIDE CHIR-99021 Ispinesib

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride SB242235 SB 203580 SB-705498 4'-CHLORO-3-METHOXYCINNAMANILIDE

SB1317 SB 269970 HYDROCHLORIDE 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime

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SB-431542/SB431542 SB 431542, >=98% 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542 SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate SB 431542 4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE 4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE InSolution? TGF-β RI Kinase Inhibitor VI, SB431542 TGF-β RI Kinase Inhibitor VI, SB431542 SB 431542 HYDRATE Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- 4-(5-benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1h-imidazol-2-yl)-benzamide hydrate 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate SB 431542 hydrate,4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide 4-[4-(2H-1,3-benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-iMidazol-2-yl]benzaMide 4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem CS-89 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide SB 431542, 98%, a potent and selective inhibitor of ALK5 SB 431542USP/EP/BP 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide TGF-β RI Kinase Inhibitor VI SB431542 SB-431542 Transforming growth factor beta receptors,inhibit,TGF-β Receptor,SB-431542,SB431542,Inhibitor 301836-41-9 C22H16N4O3xH2O Cell Biology Cell Signaling and Neuroscience BioChemical Cytokines, Growth Factors and Hormones Cytokines and Growth Factors Inhibitors Anti-cancer&immunity Smad TGF-beta Protein Kinase Signalling