Gimeracil
- CAS No.
- 103766-25-2
- Chemical Name:
- Gimeracil
- Synonyms
- CDHP;CDH3;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Cadherin-3;P-cadherin
- CBNumber:
- CB5362004
- Molecular Formula:
- C5H4ClNO2
- Molecular Weight:
- 145.54
- MDL Number:
- MFCD08458352
- MOL File:
- 103766-25-2.mol
- MSDS File:
- SDS
| Melting point | 274 °C |
|---|---|
| Boiling point | 255.1±40.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| form | solid |
| pka | 4.50±1.00(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | ZPLQIPFOCGIIHV-UHFFFAOYSA-N |
| CAS DataBase Reference | 103766-25-2(CAS DataBase Reference) |
| FDA UNII | UA8SE1325T |
| NCI Drug Dictionary | gimeracil |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
Gimeracil price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2075 | Gimeracil ≥98% (HPLC) | 103766-25-2 | 5MG | $64.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2075 | Gimeracil ≥98% (HPLC) | 103766-25-2 | 25MG | $159 | 2024-03-01 | Buy |
| TCI Chemical | C2243 | Gimeracil >98.0%(HPLC)(T) | 103766-25-2 | 1g | $89 | 2024-03-01 | Buy |
| TCI Chemical | C2243 | Gimeracil >98.0%(HPLC)(T) | 103766-25-2 | 5g | $295 | 2024-03-01 | Buy |
| Cayman Chemical | 16525 | Gimeracil ≥98% | 103766-25-2 | 100mg | $68 | 2024-03-01 | Buy |
Gimeracil Chemical Properties,Uses,Production
Description
Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3
Chemical Properties
Off-White Solid
Uses
Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.
Uses
Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)
Uses
Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
Definition
ChEBI: Gimeracil is an organic molecular entity.
References
1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712
Gimeracil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from Gimeracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Gimeracil
103766-25-2
|
US $51.00-90.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Gimeracil
103766-25-2
|
US $51.00-90.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-13 | Gimeracil
103766-25-2
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd |