4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
![4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Structure](CAS/GIF/216163-53-0.gif)
- CAS No.
- 216163-53-0
- Chemical Name:
- 4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
- Synonyms
- PD 174265;PD 174265 - CAS 216163-53-0 - Calbiochem;N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE;N-(4-((3-Bromophenyl)amino)quinazolin-6-yl)propionamide;Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
- CBNumber:
- CB5381265
- Molecular Formula:
- C17H15BrN4O
- Molecular Weight:
- 371.23
- MDL Number:
- MFCD02179208
- MOL File:
- 216163-53-0.mol
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17649 | PD 174265 ≥98% | 216163-53-0 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 17649 | PD 174265 ≥98% | 216163-53-0 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 17649 | PD 174265 ≥98% | 216163-53-0 | 5mg | $469 | 2024-03-01 | Buy |
| TRC | P218333 | PD174265 | 216163-53-0 | 2.5mg | $240 | 2021-12-16 | Buy |
| TRC | P218333 | PD174265 | 216163-53-0 | 1mg | $120 | 2021-12-16 | Buy |
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Chemical Properties,Uses,Production
Description
PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity.
Uses
PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity.
General Description
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
Biochem/physiol Actions
Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity
Enzyme inhibitor
This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4966 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4415 | 58 |
