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DM4-Sme

DM4-Sme structure

CAS No.: 796073-68-2

Chemical Name:: DM4-Sme

Synonyms: DM4-Sme;Maytansinoid DM4 Impurity 1;Maytansinoid DM4 Impurity 1-d6;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-

CBNumber:: CB53959872

Molecular Formula:: C39H56ClN3O10S2

Molecular Weight:: 826.46

MDL Number:: MFCD28400104

MOL File:: 796073-68-2.mol

Last updated:2024-07-02 08:55:11

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DM4-Sme Properties

Boiling point	963.8±65.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	9.82±0.70(Predicted)
color	White to off-white
InChIKey	LTLNAIFGVAUBEJ-GPEBISKRNA-N

DM4-Sme price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0104947	DM4-SMe ≥98.0%	796073-68-2	5mg	$495	2021-12-16	Buy
ChemScene	CS-0104947	DM4-SMe ≥98.0%	796073-68-2	10mg	$750	2021-12-16	Buy
ChemScene	CS-0104947	DM4-SMe ≥98.0%	796073-68-2	25mg	$1550	2021-12-16	Buy
ChemScene	CS-0104947	DM4-SMe ≥98.0%	796073-68-2	50mg	$2550	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0104947	5mg	$495	Buy
CS-0104947	10mg	$750	Buy
CS-0104947	25mg	$1550	Buy
CS-0104947	50mg	$2550	Buy

DM4-Sme Chemical Properties,Uses,Production

Description

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

References

[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. [2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

DM4-Sme Preparation Products And Raw materials

Raw materials

Preparation Products

DM4

DM4-Sme Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
Jinan blalong chemical co. LTD	2710913286@.com	1513643261@qq.com	China	14253	58
Shanghai Zerui Biotechnology Co., Ltd.	021-54580889 18321124657	731997554@qq.com	China	10614	58
Henan Vcommend Consultrading Co., Ltd.	13393721940	sales@vcommend.com	China	10203	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Fan De(Beijing) Biotechnology Co., Ltd.	58
Jinan blalong chemical co. LTD	58
Shanghai Zerui Biotechnology Co., Ltd.	58
Henan Vcommend Consultrading Co., Ltd.	58

DM4-Sme Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]- Maytansinoid DM4 Impurity 1 Maytansinoid DM4 Impurity 1-d6 796073-68-2