ANTI-PERILIPIN A
- CAS No.
- Chemical Name:
- ANTI-PERILIPIN A
- Synonyms
- ANTI-PERILIPIN A;ANTI-PERILIPIN A (MOUSE);POLYCLONAL ANTIBODY TO PERILIPIN A (MOUSE);Anti-Perilipin A antibody produced in rabbit
- CBNumber:
- CB5407666
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD07370428
- MOL File:
- Mol file
ANTI-PERILIPIN A Chemical Properties,Uses,Production
Uses
Anti-Perilipin A antibody produced in rabbit has also been used in:
- indirect immunofluorescence
- immunoblotting
- immunohistochemistry
General Description
Perilipin is an intracellular neutral lipid storage droplet surface protein in white and brown fat adipocytes. It is also found in lower quantity coating droplets in steroidogenic-cells of the adrenal cortex, ovaries and testicular Leydig cells, on the surface of smaller droplets containing cholesteryl esters. Perilipin has multiple isoforms, resulting from differential splicing events. Perilipin A is most abundant in adipocytes and steroidogenic cells. Perilipin B is a minor form in adipocytes. Steroidogenic cells selectively express perilipins C and D.
Biochem/physiol Actions
Perilipin is a gatekeeper protein that is involved in regulating triacylglycerol storage in adipocyte through the suppression of basal lipolysis apparently through protecting triacylglycerol against hydrolysis. Perilipin also enhances cyclic adenosine monophosphate (c-AMP)-dependent protein kinase (PKA)-stimulated lipolysis by hormone-sensitive lipase (HSL) and non-HSLs. Perilipin knockout mice exhibit reduced adipose tissue mass and resistance to diet induced obesity. Their lipid storage droplets are coated with adipose differentiation-related protein (ADRP, adipophilin), which is not phosphorylated by PKA.
ANTI-PERILIPIN A Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-PERILIPIN A Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |