ChemicalBook >> CAS DataBase List >>ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
- CAS No.
- 313254-94-3
- Chemical Name:
- ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
- Synonyms
- MMG-11;MMG 11,MMG11;ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate;2-Furancarboxylic acid, 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-, ethyl ester
- CBNumber:
- CB54109582
- Molecular Formula:
- C15H14O7
- Molecular Weight:
- 306.26746
- MDL Number:
- MFCD00499091
- MOL File:
- 313254-94-3.mol
Last updated:2024-07-02 08:55:11
| Boiling point | 565.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (326.51 mM; Need ultrasonic) |
| form | Solid |
| pka | 7.05±0.40(Predicted) |
| color | Light yellow to brown |
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6858 | MMG11 ≥97%(HPLC) | 313254-94-3 | 10 | $133 | 2021-12-16 | Buy |
| ChemScene | CS-0043485 | MMG-11 | 313254-94-3 | 10mg | $310 | 2021-12-16 | Buy |
| ChemScene | CS-0043485 | MMG-11 | 313254-94-3 | 50mg | $995 | 2021-12-16 | Buy |
| ChemScene | CS-0043485 | MMG-11 | 313254-94-3 | 100mg | $1650 | 2021-12-16 | Buy |
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Chemical Properties,Uses,Production
Biological Activity
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses[1]. MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 μM) shows no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs)[1].
storage
Store at -20°C
References
[1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160.
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate Suppliers
Global( 17)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3451 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Block Chemical Technology (Shanghai) Co., Ltd. | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 9913 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 2881924050@qq.com | China | 9903 | 58 |
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
MMG-11
MMG 11,MMG11
2-Furancarboxylic acid, 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-, ethyl ester
313254-94-3