WOBE437
- CAS No.
- 2108100-73-6
- Chemical Name:
- WOBE437
- Synonyms
- WOBE437;(2E,4E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dodecadienamide;2,4-Dodecadienamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-, (2E,4E)-
- CBNumber:
- CB54666832
- Molecular Formula:
- C22H33NO3
- Molecular Weight:
- 359.5
- MDL Number:
- MOL File:
- 2108100-73-6.mol
WOBE437 price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23506 | WOBE437 ≥97% | 2108100-73-6 | 1mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 23506 | WOBE437 ≥97% | 2108100-73-6 | 5mg | $356 | 2024-03-01 | Buy |
Cayman Chemical | 23506 | WOBE437 ≥97% | 2108100-73-6 | 10mg | $632 | 2024-03-01 | Buy |
AK Scientific | 1479EN | (2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide | 2108100-73-6 | 5mg | $495 | 2021-12-16 | Buy |
AK Scientific | 1479EN | (2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide | 2108100-73-6 | 1mg | $187 | 2021-12-16 | Buy |
WOBE437 Chemical Properties,Uses,Production
Description
WOBE437 is a potent endocannabinoid uptake inhibitor with IC50 values of 10 and 283 nM for arachidonoyl ethanolamide (AEA; ) and 2-arachidonoyl glycerol (2-AG; ) uptake, respectively, in U937 cells. It is greater than 1,000-fold selective for endocannabinoid transporters over fatty acid amide hydrolase (FAAH; ) and the 2-AG hydrolyzing enzymes MAGL, ABHD6, and ABHD12. WOBE437 inhibits AEA uptake in FAAH-deficient HMC-1 human mast cells and Neuro2a mouse neuroblastoma cells (IC50s = 137 and 55 nM, respectively) and reduces AEA uptake by 50% in rat cortical neurons when used at a concentration of 1 μM. It also reduces 2-AG uptake by 40% in Neuro2a cells at a concentration of 5 μM. In vivo, WOBE437 increases AEA and 2-AG levels by 1.5-fold in mouse brain but not peripheral tissues after intraperitoneal administration of a 10 mg/kg dose for seven days. WOBE437 (10 mg/kg) also induces a typical tetrad of hypothermia, catalepsy, analgesia, and hypomotility in mice, indicating it also acts as an indirect cannabinoid (CB) receptor 1 agonist.
WOBE437 Preparation Products And Raw materials
Raw materials
Preparation Products
WOBE437 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
Supplier | Advantage |
---|---|
BOC Sciences | 65 |
Shanghai Hongye Biotechnology Co. Ltd | 58 |
TargetMol Chemicals Inc. | 58 |